SMARCAL1 Antibody, HRP conjugated (PACO52855)
- SKU:
- PACO52855
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | SMARCAL1 Antibody, HRP conjugated (PACO52855) |
抗体コード: | PACO52855 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 protein (6-277AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. |
シノニム: | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4) (HepA-related protein) (hHARP) (Sucrose nonfermenting protein 2-like 1), SMARCAL1, HARP |
UniProt Protein Function: | SMARCAL1: ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. Defects in SMARCAL1 are a cause of Schimke immuno-osseous dysplasia (SIOD). SIOD causes spondyloepiphyseal dysplasia, renal dysfunction and T-cell immunodeficiency. Approximately half of all patients also exhibit hyperthyroidism, while around half also exhibit episodal cerebral ischema. Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. |
UniProt Protein Details: | Protein type:EC 3.6.4.-; EC 3.6.1.-; Helicase Chromosomal Location of Human Ortholog: 2q35 Cellular Component: nucleoplasm; DNA replication factor A complex; nucleus Molecular Function:DNA-dependent ATPase activity; protein binding; DNA binding; helicase activity; ATP binding Biological Process: regulation of transcription from RNA polymerase II promoter; DNA strand renaturation; chromatin modification; DNA repair; response to DNA damage stimulus; DNA metabolic process; replication fork processing Disease: Immunoosseous Dysplasia, Schimke Type |
NCBI Summary: | The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein shows sequence similarity to the E. coli RNA polymerase-binding protein HepA. Mutations in this gene are a cause of Schimke immunoosseous dysplasia (SIOD), an autosomal recessive disorder with the diagnostic features of spondyloepiphyseal dysplasia, renal dysfunction, and T-cell immunodeficiency. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NZC9 |
NCBI GenInfo Identifier: | 60390962 |
NCBI Gene ID: | 50485 |
NCBI Accession: | Q9NZC9.1 |
UniProt Related Accession: | Q9NZC9 |
Molecular Weight: | 105kDa |
NCBI Full Name: | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 |
NCBI Synonym Full Names: | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1 |
NCBI Official Symbol: | SMARCAL1 |
NCBI Official Synonym Symbols: | HARP; HHARP |
NCBI Protein Information: | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 |
UniProt Protein Name: | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 |
UniProt Synonym Protein Names: | HepA-related protein; hHARP; Sucrose nonfermenting protein 2-like 1 |
UniProt Gene Name: | SMARCAL1 |
UniProt Entry Name: | SMAL1_HUMAN |