SMARCA5 Antibody (PACO17125)
- SKU:
- PACO17125
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | SMARCA5 Antibody (PACO17125) |
抗体コード: | PACO17125 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human SMARCA5 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-7: Hepg2 cells, MCF7 cells, Jurkat cells, hela cells, A431 cells, K562 cells, lncap cells, Primary antibody: PACO17125(SMARCA5 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. |
バックグラウンド: | The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. |
シノニム: | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 |
UniProt Protein Function: | SMARCA5: an ubiquitous enzyme with ATP-dependent DNA helicase activity. Possesses intrinsic ATP-dependent nucleosome remodelling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin in vitro; this may require intact histone H4 tails. The catalytic subunit of the four known chromatin remodelling complexes: CHRAC, RSF, ACF/WCRF, and WICH. Each complex contains subunits which may regulate the specificity or catalytic activity of SMARCA5. Overexpressed in CD34-positive erythrocyte progenitor cells in acute myeloid leukemia. Down-regulation correlates with hematologic remission following chemotherapy. Belongs to the SNF2/RAD54 helicase family, ISWI subfamily. |
UniProt Protein Details: | Protein type:Helicase; EC 3.6.4.-; Transcription factor; EC 3.6.1.-; Histone-binding Chromosomal Location of Human Ortholog: 4q31.1-q31.2 Cellular Component: nucleoplasm; chromatin silencing complex; RSF complex; nuclear replication fork; nucleolus; condensed chromosome; nucleus Molecular Function:protein binding; DNA binding; histone binding; nucleosome binding; ATPase activity; helicase activity; ATP binding Biological Process: chromatin silencing at rDNA; chromatin remodeling; regulation of transcription from RNA polymerase II promoter; nucleosome assembly; DNA replication-independent nucleosome assembly at centromere; negative regulation of gene expression, epigenetic; double-strand break repair; transcription initiation; ATP-dependent chromatin remodeling; gene expression; regulation of gene expression, epigenetic; nucleosome positioning |
NCBI Summary: | The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein. [provided by RefSeq, Jul 2008] |
UniProt Code: | O60264 |
NCBI GenInfo Identifier: | 57014128 |
NCBI Gene ID: | 8467 |
NCBI Accession: | O60264.1 |
UniProt Related Accession: | O60264 |
Molecular Weight: | 1052 |
NCBI Full Name: | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 |
NCBI Synonym Full Names: | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 |
NCBI Official Symbol: | SMARCA5 |
NCBI Official Synonym Symbols: | ISWI; SNF2H; hISWI; hSNF2H; WCRF135 |
NCBI Protein Information: | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5; sucrose nonfermenting-like 5; sucrose nonfermenting protein 2 homolog; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5 |
UniProt Protein Name: | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 |
UniProt Synonym Protein Names: | Sucrose nonfermenting protein 2 homolog; hSNF2H |
Protein Family: | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily |
UniProt Gene Name: | SMARCA5 |
UniProt Entry Name: | SMCA5_HUMAN |