SMAD6 Antibody (PACO04273)
- SKU:
- PACO04273
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | SMAD6 Antibody |
抗体コード: | PACO04273 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300 |
反応性: | Human, Mouse |
免疫原: | synthesized peptide derived from the Internal region of human Smad6. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | SMAD6; MADH6; Mothers against decapentaplegic homolog 6; MAD homolog 6; Mothers against DPP homolog 6; SMAD family member 6; SMAD 6; Smad6; hSMAD6 |
UniProt Protein Function: | SMAD6: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions. Interacts with NEDD4L. Interacts with WWP1. Interacts with RNF111 and AXIN1. Interacts with TGF-beta type I receptor superfamily members, SMAD1, HOXC8 and HOXC9. Interacts with STAMBP and PRKX. Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue. Belongs to the dwarfin/SMAD family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 15q22.31 Cellular Component: transcription factor complex; protein complex; cytoplasm; cytosol; nucleus Molecular Function:identical protein binding; protein binding; ubiquitin protein ligase binding; metal ion binding; chromatin binding; transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity; transcription factor activity Biological Process: BMP signaling pathway; fat cell differentiation; negative regulation of cell proliferation; zygotic determination of dorsal/ventral axis; transcription, DNA-dependent; ureteric bud development; response to estrogen stimulus; transforming growth factor beta receptor signaling pathway; immune response; negative regulation of transforming growth factor beta receptor signaling pathway; cell-substrate adhesion; negative regulation of apoptosis; negative regulation of BMP signaling pathway Disease: Aortic Valve Disease 2 |
NCBI Summary: | The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.[provided by RefSeq, Sep 2014] |
UniProt Code: | O43541 |
NCBI GenInfo Identifier: | 115502451 |
NCBI Gene ID: | 4091 |
NCBI Accession: | O43541.2 |
UniProt Related Accession: | O43541 |
Molecular Weight: | |
NCBI Full Name: | Mothers against decapentaplegic homolog 6 |
NCBI Synonym Full Names: | SMAD family member 6 |
NCBI Official Symbol: | SMAD6 |
NCBI Official Synonym Symbols: | AOVD2; MADH6; MADH7; HsT17432 |
NCBI Protein Information: | mothers against decapentaplegic homolog 6 |
UniProt Protein Name: | Mothers against decapentaplegic homolog 6 |
UniProt Synonym Protein Names: | SMAD family member 6; SMAD 6; Smad6; hSMAD6 |
Protein Family: | Mothers against decapentaplegic |
UniProt Gene Name: | SMAD6 |
UniProt Entry Name: | SMAD6_HUMAN |