SLU7 Antibody (PACO50022)
- SKU:
- PACO50022
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | SLU7 Antibody (PACO50022) |
抗体コード: | PACO50022 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human Pre-mRNA-splicing factor SLU7 protein (138-310AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: K562 whole cell lysate, Mouse brain tissue. All lanes: SLU7 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 69 kDa. Observed band size: 69 kDa.. | |
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO50022 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human liver cancer using PACO50022 at dilution of 1:100. |
バックグラウンド: | Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. |
シノニム: | Pre-mRNA-splicing factor SLU7 (hSlu7), SLU7 |
UniProt Protein Function: | SLU7: Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'- splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. Belongs to the SLU7 family. |
UniProt Protein Details: | Protein type:Spliceosome; RNA splicing; RNA processing Chromosomal Location of Human Ortholog: 5q33.3 Cellular Component: cytoplasm; intracellular membrane-bound organelle; membrane; nuclear speck; nucleoplasm; nucleus; small nuclear ribonucleoprotein complex; spliceosome Molecular Function:pre-mRNA 3'-splice site binding; protein binding; second spliceosomal transesterification activity; zinc ion binding Biological Process: alternative nuclear mRNA splicing, via spliceosome; intracellular protein transport; mRNA 3'-end processing; mRNA export from nucleus; nuclear mRNA 3'-splice site recognition; nuclear mRNA splicing, via spliceosome; RNA export from nucleus; RNA splicing, via transesterification reactions; termination of RNA polymerase II transcription |
NCBI Summary: | Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq, Jul 2008] |
UniProt Code: | O95391 |
NCBI GenInfo Identifier: | 262527559 |
NCBI Gene ID: | 10569 |
NCBI Accession: | O95391.2 |
UniProt Secondary Accession: | O95391,Q3LUJ0, Q3LUJ1, Q6RXQ5, Q96FM9, D3DQK2, |
UniProt Related Accession: | O95391 |
Molecular Weight: | 68,387 Da |
NCBI Full Name: | Pre-mRNA-splicing factor SLU7 |
NCBI Synonym Full Names: | SLU7 homolog, splicing factor |
NCBI Official Symbol: | SLU7 |
NCBI Official Synonym Symbols: | 9G8; hSlu7 |
NCBI Protein Information: | pre-mRNA-splicing factor SLU7 |
UniProt Protein Name: | Pre-mRNA-splicing factor SLU7 |
Protein Family: | Pre-mRNA-splicing factor |
UniProt Gene Name: | SLU7 |
UniProt Entry Name: | SLU7_HUMAN |