SLC8B1 Antibody (PACO20486)
- SKU:
- PACO20486
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SLC8B1 Antibody (PACO20486) |
抗体コード: | PACO20486 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthetic peptide of human SLC8B1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20486(SLC8B1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | Gel: 8%SDS-PAGE,Lysate: 40 µg,Lane 1-2: Human placenta tissue, Human normal kidney tissue,Primary antibody: PACO20486(SLC8B1 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20486(SLC8B1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion. |
シノニム: | solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 |
UniProt Protein Function: | Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca2+ entry (SOCE) and Ca2+ release-activated Ca2+ (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyte chemotaxis (). Able to transport Ca2+ in exchange of either Li+ or Na+, explaining how Li+ catalyzes Ca2+ exchange (PubMed:15060069). In contrast to other members of the family its function is independent of K+ (PubMed:15060069). |
UniProt Protein Details: | |
NCBI Summary: | SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion (Cai and Lytton, 2004 [PubMed 14625281]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q6J4K2 |
NCBI GenInfo Identifier: | 1060099165 |
NCBI Gene ID: | 80024 |
NCBI Accession: | NP_001317395.1 |
UniProt Secondary Accession: | Q6J4K2,Q4KMS9, Q6J4K1, Q9H6I8, A6NP50 |
UniProt Related Accession: | Q6J4K2 |
Molecular Weight: | 58,087 Da |
NCBI Full Name: | mitochondrial sodium/calcium exchanger protein isoform 2 |
NCBI Synonym Full Names: | solute carrier family 8 member B1 |
NCBI Official Symbol: | SLC8B1 |
NCBI Official Synonym Symbols: | NCLX; NCKX6; SLC24A6 |
NCBI Protein Information: | mitochondrial sodium/calcium exchanger protein |
UniProt Protein Name: | Mitochondrial sodium/calcium exchanger protein |
UniProt Synonym Protein Names: | Na(+)/K(+)/Ca(2+)-exchange protein 6 |
Protein Family: | |
UniProt Gene Name: | SLC8B1 |
UniProt Entry Name: |