バックグラウンド: | Functions as permease involved in the transport of the cationic amino acid, (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acid, (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acid, (arginine, lysine and ornithine). May play a role in classical or alternative activation of macrophages via its role in arginine transport. |
シノニム: | Cationic amino acid, transporter 2 (CAT-2) (CAT2) (Low affinity cationic amino acid, transporter 2) (Solute carrier family 7 member 2), SLC7A2, ATRC2 CAT2 |
UniProt Protein Function: | Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) (PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport. |
NCBI Summary: | The protein encoded by this gene is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
UniProt Code: | P52569 |
NCBI GenInfo Identifier: | 258614005 |
NCBI Gene ID: | 6542 |
NCBI Accession: | NP_001008539.3 |
UniProt Secondary Accession: | P52569,O15291, O15292, Q14CQ6, Q6NSZ7, Q86TC6, B7ZL54 |
UniProt Related Accession: | P52569 |
Molecular Weight: | 75,986 Da |
NCBI Full Name: | cationic amino acid transporter 2 isoform 2 |
NCBI Synonym Full Names: | solute carrier family 7 member 2 |
NCBI Official Symbol: | SLC7A2 |
NCBI Official Synonym Symbols: | CAT2; ATRC2; HCAT2 |
NCBI Protein Information: | cationic amino acid transporter 2 |
UniProt Protein Name: | Cationic amino acid transporter 2 |
UniProt Synonym Protein Names: | Low affinity cationic amino acid transporter 2; Solute carrier family 7 member 2 |
Protein Family: | Catalase isozyme |
UniProt Gene Name: | SLC7A2 |