SLC6A8 Antibody (PACO20523)
- SKU:
- PACO20523
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SLC6A8 Antibody (PACO20523) |
抗体コード: | PACO20523 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthetic peptide of human SLC6A8 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20523(SLC6A8 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20523(SLC6A8 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. |
シノニム: | solute carrier family 6 (neurotransmitter transporter), member 8 |
UniProt Protein Function: | SLC6A8: Required for the uptake of creatine in muscles and brain. Defects in SLC6A8 are the cause of X-linked creatine deficiency syndrome (XL-CDS). XL-CDS causes developmental delay, hypotonia, mental retardation, seizures, short stature and midface hypoplasia. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Transporter, SLC family; Motility/polarity/chemotaxis; Transporter; Membrane protein, integral Chromosomal Location of Human Ortholog: Xq28 Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane Molecular Function:creatine:sodium symporter activity Biological Process: creatine metabolic process; creatine transport; muscle contraction; transport Disease: Cerebral Creatine Deficiency Syndrome 1 |
NCBI Summary: | The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] |
UniProt Code: | P48029 |
NCBI GenInfo Identifier: | 1352529 |
NCBI Gene ID: | 6535 |
NCBI Accession: | P48029.1 |
UniProt Secondary Accession: | P48029,Q13032, Q66I36, B2KY47, B4DIA3, E9PFC0, |
UniProt Related Accession: | P48029 |
Molecular Weight: | 58,453 Da |
NCBI Full Name: | Sodium- and chloride-dependent creatine transporter 1 |
NCBI Synonym Full Names: | solute carrier family 6 member 8 |
NCBI Official Symbol: | SLC6A8 |
NCBI Official Synonym Symbols: | CRT; CT1; CRTR; CTR5; CCDS1 |
NCBI Protein Information: | sodium- and chloride-dependent creatine transporter 1 |
UniProt Protein Name: | Sodium- and chloride-dependent creatine transporter 1 |
UniProt Synonym Protein Names: | Solute carrier family 6 member 8 |
Protein Family: | Sodium- and chloride-dependent creatine transporter |
UniProt Gene Name: | SLC6A8 |
UniProt Entry Name: | SC6A8_HUMAN |