バックグラウンド: | Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acid, including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. |
シノニム: | Sodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8), SLC5A8, AIT SMCT SMCT1 |
UniProt Protein Function: | SLC5A8: Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D- hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D- lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. |
UniProt Protein Details: | Protein type:Tumor suppressor; Transporter; Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral; Apoptosis Chromosomal Location of Human Ortholog: 12q23.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:monocarboxylic acid transmembrane transporter activity; passive transmembrane transporter activity; symporter activity Biological Process: ion transport |
NCBI Summary: | SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002 [PubMed 12107270]) and monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al., 2004 [PubMed 15322102]). In kidney, SLC5A8 functions as a high-affinity sodium-coupled lactate transporter involved in reabsorption of lactate and maintenance of blood lactate levels (Thangaraju et al., 2006 [PubMed 16873376]).[supplied by OMIM, Dec 2008] |
UniProt Code: | Q8N695 |
NCBI GenInfo Identifier: | 296452898 |
NCBI Gene ID: | 160728 |
NCBI Accession: | Q8N695.2 |
UniProt Secondary Accession: | Q8N695,Q2TB99, Q7Z2H9, |
UniProt Related Accession: | Q8N695 |
Molecular Weight: | 66,578 Da |
NCBI Full Name: | Sodium-coupled monocarboxylate transporter 1 |
NCBI Synonym Full Names: | solute carrier family 5 member 8 |
NCBI Official Symbol: | SLC5A8 |
NCBI Official Synonym Symbols: | AIT; SMCT; SMCT1 |
NCBI Protein Information: | sodium-coupled monocarboxylate transporter 1 |
UniProt Protein Name: | Sodium-coupled monocarboxylate transporter 1 |
UniProt Synonym Protein Names: | Apical iodide transporter; Electrogenic sodium monocarboxylate cotransporter; Sodium iodide-related cotransporter; Solute carrier family 5 member 8 |
Protein Family: | Sodium-coupled monocarboxylate transporter |
UniProt Gene Name: | SLC5A8 |
UniProt Entry Name: | SC5A8_HUMAN |