SLC5A5 Antibody (PACO59273)
- SKU:
- PACO59273
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SLC5A5 Antibody (PACO59273) |
抗体コード: | PACO59273 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:200 |
反応性: | Human, Rat |
免疫原: | Recombinant Human Sodium/iodide cotransporter protein (547-643AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Rat stomach tissue. All lanes: SLC5A5 antibody at 3.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 69 kDa. Observed band size: 69 kDa. | |
IHC image of PACO59273 diluted at 1:500 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. | |
IHC image of PACO59273 diluted at 1:500 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
バックグラウンド: | Mediates iodide uptake in the thyroid gland. |
シノニム: | Sodium/iodide cotransporter (Na(+)/I(-) cotransporter) (Sodium-iodide symporter) (Na(+)/I(-) symporter) (Solute carrier family 5 member 5), SLC5A5, NIS |
UniProt Protein Function: | SLC5A5: Mediates iodide uptake in the thyroid gland. Defects in SLC5A5 are the cause of thyroid dyshormonogenesis 1 (TDH1). A disorder characterized by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Chromosomal Location of Human Ortholog: 19p13.11 Cellular Component: integral component of membrane; nucleus; plasma membrane Molecular Function:iodide transmembrane transporter activity; sodium:iodide symporter activity Biological Process: iodide transport; ion transport; thyroid hormone generation; transport Disease: Thyroid Dyshormonogenesis 1 |
NCBI Summary: | This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.[provided by RefSeq, Sep 2009] |
UniProt Code: | Q92911 |
NCBI GenInfo Identifier: | 4507035 |
NCBI Gene ID: | 6528 |
NCBI Accession: | NP_000444.1 |
UniProt Secondary Accession: | Q92911,O43702, Q2M335, Q9NYB6, |
UniProt Related Accession: | Q92911 |
Molecular Weight: | |
NCBI Full Name: | sodium/iodide cotransporter |
NCBI Synonym Full Names: | solute carrier family 5 member 5 |
NCBI Official Symbol: | SLC5A5 |
NCBI Official Synonym Symbols: | NIS; TDH1 |
NCBI Protein Information: | sodium/iodide cotransporter |
UniProt Protein Name: | Sodium/iodide cotransporter |
UniProt Synonym Protein Names: | Sodium-iodide symporter; Na(+)/I(-) symporter; Solute carrier family 5 member 5 |
UniProt Gene Name: | SLC5A5 |
Antibodies |
Anti-SLC5A5 Antibody (CAB9605) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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