SLC3A1 Antibody, HRP conjugated (PACO52443)
- SKU:
- PACO52443
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | SLC3A1 Antibody, HRP conjugated (PACO52443) |
抗体コード: | PACO52443 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Neutral and basic amino acid, transport protein rBAT protein (1-68AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acid, (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule. |
シノニム: | Neutral and basic amino acid, transport protein rBAT (NBAT) (D2h) (Solute carrier family 3 member 1) (b(0,+)-type amino acid, transport protein), SLC3A1, RBAT |
UniProt Protein Function: | SLC3A1: Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule. Defects in SLC3A1 are a cause of cystinuria type 1 (CSNU1). Cystinuria (CSNU) arises from impaired transport of cystine and dibasic amino acids through the epithelial cells of the renal tubule and gastrointestinal tract. Defects in SLC3A1 are a cause of hypotonia-cystinuria syndrome (HCS). HCS is characterized generalized hypotonia at birth, nephrolithiasis, growth hormone deficiency, minor facial dysmorphism, failure to thrive, followed by hyperphagia and rapid weight gain in late childhood. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Mitochondrial; Transporter Chromosomal Location of Human Ortholog: 2p16.3 Cellular Component: brush border membrane; membrane; plasma membrane Molecular Function:amino acid transmembrane transporter activity; basic amino acid transmembrane transporter activity; L-cystine transmembrane transporter activity; protein binding Biological Process: amino acid metabolic process; amino acid transport; basic amino acid transport; L-cystine transport Disease: Cystinuria |
NCBI Summary: | This gene encodes a type II membrane glycoprotein which is one of the components of the renal amino acid transporter which transports neutral and basic amino acids in the renal tubule and intestinal tract. Mutations and deletions in this gene are associated with cystinuria. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q07837 |
NCBI GenInfo Identifier: | 67472674 |
NCBI Gene ID: | 6519 |
NCBI Accession: | Q07837.2 |
UniProt Secondary Accession: | Q07837,O00658, Q15295, Q4J6B4, Q4J6B5, Q4J6B6, Q4J6B7 Q4J6B8, Q4J6B9, Q52M92, Q52M94, A8K0S1, |
UniProt Related Accession: | Q07837 |
Molecular Weight: | 63,401 Da |
NCBI Full Name: | Neutral and basic amino acid transport protein rBAT |
NCBI Synonym Full Names: | solute carrier family 3 member 1 |
NCBI Official Symbol: | SLC3A1 |
NCBI Official Synonym Symbols: | D2H; ATR1; NBAT; RBAT; CSNU1 |
NCBI Protein Information: | neutral and basic amino acid transport protein rBAT |
UniProt Protein Name: | Neutral and basic amino acid transport protein rBAT |
UniProt Synonym Protein Names: | D2h; Solute carrier family 3 member 1; b(0,+)-type amino acid transport protein |
Protein Family: | Neutral and basic amino acid transport protein |
UniProt Gene Name: | SLC3A1 |
UniProt Entry Name: | SLC31_HUMAN |