UniProt Protein Function: | SLC29A4: Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to changes in membrane potential. Weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep, and nitrobenzylthioinosine. May play a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia. Belongs to the SLC29A/ENT transporter (TC 2.A.57) family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Transporter; Transporter, SLC family; Membrane protein, multi-passChromosomal Location of Human Ortholog: 7p22.1Cellular Component: apical plasma membrane; integral to membrane; plasma membraneMolecular Function: nucleoside transmembrane transporter activity; monoamine transmembrane transporter activityBiological Process: monoamine transport; transmembrane transport |
UniProt Protein Details: | |
NCBI Summary: | This gene is a member of the SLC29 family and encodes a plasma membrane protein with 11 transmembrane helices. This protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q7RTT9 |
NCBI GenInfo Identifier: | 530384568 |
NCBI Gene ID: | 222962 |
NCBI Accession: | XP_005249715.1 |
UniProt Secondary Accession: | Q7RTT9,Q6PJ08, Q86WY8, Q8NAR3, Q8NBM2 |
UniProt Related Accession: | Q7RTT9 |
Molecular Weight: | 58,059 Da |
NCBI Full Name: | equilibrative nucleoside transporter 4 isoform X2 |
NCBI Synonym Full Names: | solute carrier family 29 (equilibrative nucleoside transporter), member 4 |
NCBI Official Symbol: | SLC29A4 |
NCBI Official Synonym Symbols: | ENT4; PMAT |
NCBI Protein Information: | equilibrative nucleoside transporter 4; hENT4; solute carrier family 29 member 4; plasma membrane monoamine transporter; solute carrier family 29 (nucleoside transporters), member 4 |
UniProt Protein Name: | Equilibrative nucleoside transporter 4 |
UniProt Synonym Protein Names: | Plasma membrane monoamine transporter; Solute carrier family 29 member 4 |
Protein Family: | Equilibrative nucleoside transporter |
UniProt Gene Name: | SLC29A4 |
UniProt Entry Name: | S29A4_HUMAN |