SLC26A6 Antibody, HRP conjugated (PACO57433)
- SKU:
- PACO57433
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Description
抗体名: | SLC26A6 Antibody, HRP conjugated (PACO57433) |
抗体コード: | PACO57433 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Solute carrier family 26 member 6 protein (554-668AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid, base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Function in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH. |
シノニム: | Solute carrier family 26 member 6 (Anion exchange transporter) (Pendrin-like protein 1) (Pendrin-L1), SLC26A6 |
UniProt Protein Function: | SLC26A6: Does not seem to be involved in anion transport. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Chromosomal Location of Human Ortholog: 3p21.31 Cellular Component: apical plasma membrane; basolateral plasma membrane; brush border membrane; integral to membrane; integral to plasma membrane; membrane; plasma membrane; vesicle; vesicle membrane Molecular Function:anion:anion antiporter activity; bicarbonate transmembrane transporter activity; chloride channel activity; chloride transmembrane transporter activity; efflux transmembrane transporter activity; formate efflux transmembrane transporter activity; formate transmembrane transporter activity; formate uptake transmembrane transporter activity; inorganic anion exchanger activity; oxalate transmembrane transporter activity; PDZ domain binding; sulfate transmembrane transporter activity Biological Process: bicarbonate transport; chloride transport; epithelial fluid transport; formate transport; intestinal absorption; intracellular pH elevation; ion transport; mannitol transport; oxalate transport; oxalic acid secretion; regulation of intracellular pH; regulation of membrane potential; sperm capacitation; sulfate transport; transepithelial chloride transport |
NCBI Summary: | This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2013] |
UniProt Code: | Q9BXS9 |
NCBI GenInfo Identifier: | 20140224 |
NCBI Gene ID: | 65010 |
NCBI Accession: | Q9BXS9.1 |
UniProt Secondary Accession: | Q9BXS9,Q548A7, Q96Q90, Q9NQU1, B4DMZ1, |
UniProt Related Accession: | Q9BXS9 |
Molecular Weight: | 83kDa |
NCBI Full Name: | Solute carrier family 26 member 6 |
NCBI Synonym Full Names: | solute carrier family 26 member 6 |
NCBI Official Symbol: | SLC26A6 |
NCBI Protein Information: | solute carrier family 26 member 6 |
UniProt Protein Name: | Solute carrier family 26 member 6 |
UniProt Synonym Protein Names: | Anion exchange transporter; Pendrin-like protein 1; Pendrin-L1 |
Protein Family: | Solute carrier family |
UniProt Gene Name: | SLC26A6 |