SLC12A1 Antibody (PACO14995)
- SKU:
- PACO14995
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SLC12A1 Antibody (PACO14995) |
抗体コード: | PACO14995 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
反応性: | Human, Mouse, Rat |
免疫原: | Fusion protein of human SLC12A1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO14995(SLC12A1 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal kidney tissue, Primary antibody: PACO14995(SLC12A1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14995(SLC12A1 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven. |
シノニム: | Solute carrier family 12 (sodium/potassium/chloride transporters), member 1 |
UniProt Protein Function: | NKCC2: Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. Kidney specific. Activated by WNK3. Belongs to the SLC12A transporter family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transporter; Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 15q15-q21.1 Cellular Component: membrane; apical plasma membrane; plasma membrane; integral to membrane Molecular Function:sodium:potassium:chloride symporter activity Biological Process: transport; sodium ion transport; ion transport; chloride transport; excretion; kidney development; transmembrane transport; potassium ion transport; chemical homeostasis Disease: Bartter Syndrome, Antenatal, Type 1 |
NCBI Summary: | This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.[provided by RefSeq, May 2010] |
UniProt Code: | Q13621 |
NCBI GenInfo Identifier: | 212276464 |
NCBI Gene ID: | 6557 |
NCBI Accession: | Q13621.2 |
UniProt Related Accession: | Q13621 |
Molecular Weight: | Observed: 135 kDaPredicted: 122 kDa |
NCBI Full Name: | Solute carrier family 12 member 1 |
NCBI Synonym Full Names: | solute carrier family 12 member 1 |
NCBI Official Symbol: | SLC12A1 |
NCBI Official Synonym Symbols: | BSC1; NKCC2 |
NCBI Protein Information: | solute carrier family 12 member 1 |
UniProt Protein Name: | Solute carrier family 12 member 1 |
UniProt Synonym Protein Names: | Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; Kidney-specific Na-K-Cl symporter |
UniProt Gene Name: | SLC12A1 |
UniProt Entry Name: | S12A1_HUMAN |
Antibodies | ELISA Kits |
Anti-SLC12A1 Antibody (CAB12999) | Human SLC12A1 / Solute carrier family 12 member 1 ELISA Kit |
Human Solute carrier family 12 member 1 (SLC12A1) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |