SIGLEC7 Antibody (PACO19412)
- SKU:
- PACO19412
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SIGLEC7 Antibody (PACO19412) |
抗体コード: | PACO19412 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
反応性: | Human |
免疫原: | Synthetic peptide of human SIGLEC7 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19412(SIGLEC7 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: PACO19412(SIGLEC7 Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19412(SIGLEC7 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | Sialic acid, binding Ig-like lectin 7 is a protein that in humans is encoded by the SIGLEC7 gene. SIGLEC7 has also been designated as CD328 (cluster of differentiation 328). Putative adhesion molecule that mediates sialic-acid, dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid, Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid, recognition site may be masked by cis interactions with sialic acid, on the same cell surface. |
シノニム: | sialic acid, binding Ig-like lectin 7 |
UniProt Protein Function: | SIGLEC7: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: integral to plasma membrane Molecular Function:receptor activity; carbohydrate binding Biological Process: cell adhesion |
UniProt Code: | Q9Y286 |
NCBI GenInfo Identifier: | 25009269 |
NCBI Gene ID: | 27036 |
NCBI Accession: | Q9Y286.1 |
UniProt Related Accession: | Q9Y286 |
Molecular Weight: | |
NCBI Full Name: | Sialic acid-binding Ig-like lectin 7 |
NCBI Synonym Full Names: | sialic acid binding Ig like lectin 7 |
NCBI Official Symbol: | SIGLEC7 |
NCBI Official Synonym Symbols: | p75; QA79; AIRM1; CD328; CDw328; D-siglec; SIGLEC-7; SIGLECP2; SIGLEC19P; p75/AIRM1 |
NCBI Protein Information: | sialic acid-binding Ig-like lectin 7 |
UniProt Protein Name: | Sialic acid-binding Ig-like lectin 7 |
UniProt Synonym Protein Names: | Adhesion inhibitory receptor molecule 1; AIRM-1; CDw328; D-siglec; QA79 membrane protein; p75; CD_antigen: CD328 |
UniProt Gene Name: | SIGLEC7 |
UniProt Entry Name: | SIGL7_HUMAN |