SIGLEC7 Antibody, Biotin conjugated (PACO51221)
- SKU:
- PACO51221
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | SIGLEC7 Antibody, Biotin conjugated (PACO51221) |
抗体コード: | PACO51221 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Sialic acid, binding Ig-like lectin 7 protein (377-467AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Putative adhesion molecule that mediates sialic-acid, dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid, Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid, recognition site may be masked by cis interactions with sialic acid, on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). |
シノニム: | Sialic acid, binding Ig-like lectin 7 (Siglec-7) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (CDw328) (D-siglec) (QA79 membrane protein) (p75) (CD antigen CD328), SIGLEC7, AIRM1 |
UniProt Protein Function: | SIGLEC7: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: integral to plasma membrane Molecular Function:receptor activity; carbohydrate binding Biological Process: cell adhesion |
UniProt Code: | Q9Y286 |
NCBI GenInfo Identifier: | 25009269 |
NCBI Gene ID: | 27036 |
NCBI Accession: | Q9Y286.1 |
UniProt Related Accession: | Q9Y286 |
Molecular Weight: | |
NCBI Full Name: | Sialic acid-binding Ig-like lectin 7 |
NCBI Synonym Full Names: | sialic acid binding Ig like lectin 7 |
NCBI Official Symbol: | SIGLEC7 |
NCBI Official Synonym Symbols: | p75; QA79; AIRM1; CD328; CDw328; D-siglec; SIGLEC-7; SIGLECP2; SIGLEC19P; p75/AIRM1 |
NCBI Protein Information: | sialic acid-binding Ig-like lectin 7 |
UniProt Protein Name: | Sialic acid-binding Ig-like lectin 7 |
UniProt Synonym Protein Names: | Adhesion inhibitory receptor molecule 1; AIRM-1; CDw328; D-siglec; QA79 membrane protein; p75; CD_antigen: CD328 |
UniProt Gene Name: | SIGLEC7 |
UniProt Entry Name: | SIGL7_HUMAN |