SHOC2 Antibody, Biotin conjugated (PACO52885)
- SKU:
- PACO52885
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | SHOC2 Antibody, Biotin conjugated (PACO52885) |
抗体コード: | PACO52885 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Leucine-rich repeat protein SHOC-2 protein (3-89AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. |
シノニム: | Leucine-rich repeat protein SHOC-2 (Protein soc-2 homolog) (Protein sur-8 homolog), SHOC2, KIAA0862 |
UniProt Protein Function: | SHOC2: Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. Defects in SHOC2 are the cause of Noonan syndrome-like disorder with loose anagen hair (NSLH). A syndrome characterized by Noonan dysmorphic features such as macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck, pectus anomalies, in association with pluckable, sparse, thin and slow-growing hair. Belongs to the SHOC2 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 10q25 Cellular Component: cytoplasm; nucleoplasm; nucleus; protein phosphatase type 1 complex Molecular Function:protein binding; protein phosphatase 1 binding; protein phosphatase binding; protein phosphatase regulator activity Biological Process: positive regulation of Ras protein signal transduction Disease: Noonan Syndrome-like Disorder With Loose Anagen Hair |
NCBI Summary: | This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. [provided by RefSeq, May 2010] |
UniProt Code: | Q9UQ13 |
NCBI GenInfo Identifier: | 14423936 |
NCBI Gene ID: | 8036 |
NCBI Accession: | Q9UQ13.2 |
UniProt Secondary Accession: | Q9UQ13,O76063, Q5VZS8, Q5VZS9, A8K9W8, B3KR23, |
UniProt Related Accession: | Q9UQ13 |
Molecular Weight: | 59,743 Da |
NCBI Full Name: | Leucine-rich repeat protein SHOC-2 |
NCBI Synonym Full Names: | SHOC2, leucine rich repeat scaffold protein |
NCBI Official Symbol: | SHOC2 |
NCBI Official Synonym Symbols: | SOC2; SUR8; SIAA0862 |
NCBI Protein Information: | leucine-rich repeat protein SHOC-2 |
UniProt Protein Name: | Leucine-rich repeat protein SHOC-2 |
UniProt Synonym Protein Names: | Protein soc-2 homolog; Protein sur-8 homolog |
Protein Family: | Leucine-rich repeat protein |
UniProt Gene Name: | SHOC2 |
UniProt Entry Name: | SHOC2_HUMAN |