SHANK2 Antibody (PACO57592)
- SKU:
- PACO57592
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SHANK2 Antibody (PACO57592) |
抗体コード: | PACO57592 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
反応性: | Human |
免疫原: | Recombinant Human SH3 and multiple ankyrin repeat domains protein 2 protein (728-822AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
IHC image of PACO57592 diluted at 1:400 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. | |
IHC image of PACO57592 diluted at 1:400 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
バックグラウンド: | Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. |
シノニム: | SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (Proline-rich synapse-associated protein 1), SHANK2, CORTBP1 KIAA1022 PROSAP1 |
UniProt Protein Function: | Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. |
NCBI Summary: | This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] |
UniProt Code: | Q9UPX8 |
NCBI GenInfo Identifier: | 254763402 |
NCBI Gene ID: | 22941 |
NCBI Accession: | Q9UPX8.3 |
UniProt Secondary Accession: | Q9UPX8,Q3Y8G9, Q52LK2, Q9UKP1, C0SPG8, C0SPG9, |
UniProt Related Accession: | Q9UPX8 |
Molecular Weight: | 134,931 Da |
NCBI Full Name: | SH3 and multiple ankyrin repeat domains protein 2 |
NCBI Synonym Full Names: | SH3 and multiple ankyrin repeat domains 2 |
NCBI Official Symbol: | SHANK2 |
NCBI Official Synonym Symbols: | SHANK; AUTS17; CORTBP1; CTTNBP1; ProSAP1; SPANK-3 |
NCBI Protein Information: | SH3 and multiple ankyrin repeat domains protein 2 |
UniProt Protein Name: | SH3 and multiple ankyrin repeat domains protein 2 |
UniProt Synonym Protein Names: | Cortactin-binding protein 1; CortBP1; Proline-rich synapse-associated protein 1 |
Protein Family: | SH3 and multiple ankyrin repeat domains protein |
UniProt Gene Name: | SHANK2 |
UniProt Entry Name: | SHAN2_HUMAN |