UniProt Protein Function: | SH3GLB1: May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Binds DNM1, HTT, AMPH, BIN1 and ARFGAP1. Homodimer, and heterodimer with SH3GLB2. Binds BAX. Induction of apoptosis augments BAX binding. Highly expressed in heart, skeletal muscle, kidney and placenta. Detected at lower levels in brain, colon, thymus, spleen, liver, small intestine, lung and peripheral blood leukocytes. Belongs to the endophilin family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Mitochondrial; Apoptosis; EC 2.3.1.-; Autophagy; Transferase Chromosomal Location of Human Ortholog: 1p22 Cellular Component: cytoplasm; midbody Molecular Function:identical protein binding; protein binding; protein homodimerization activity Biological Process: autophagic cell death; cellular response to amino acid starvation; cellular response to glucose starvation; positive regulation of autophagy; positive regulation of protein oligomerization; protein oligomerization; receptor catabolic process; regulation of cytokinesis; regulation of macroautophagy; regulation of protein stability |
NCBI Summary: | This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011] |
UniProt Code: | Q9Y371 |
NCBI GenInfo Identifier: | 41018158 |
NCBI Gene ID: | 51100 |
NCBI Accession: | Q9Y371.1 |
UniProt Secondary Accession: | Q9Y371,Q5H8U5, Q9H3Z0, Q9NR47, Q9NYA9, B4E182, |
UniProt Related Accession: | Q9Y371 |
Molecular Weight: | 29,318 Da |
NCBI Full Name: | Endophilin-B1 |
NCBI Synonym Full Names: | SH3 domain containing GRB2 like endophilin B1 |
NCBI Official Symbol: | SH3GLB1 |
NCBI Official Synonym Symbols: | Bif-1; CGI-61; PPP1R70; dJ612B15.2 |
NCBI Protein Information: | endophilin-B1 |
UniProt Protein Name: | Endophilin-B1 |
UniProt Synonym Protein Names: | Bax-interacting factor 1; Bif-1; SH3 domain-containing GRB2-like protein B1 |
Protein Family: | Endophilin |
UniProt Gene Name: | SH3GLB1 |
UniProt Entry Name: | SHLB1_HUMAN |