SETMAR Antibody (PACO05022)
- SKU:
- PACO05022
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | SETMAR Antibody (PACO05022) |
抗体コード: | PACO05022 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:40000, IHC:1:100-1:300 |
反応性: | Human |
免疫原: | Synthesized peptide derived from the Internal region of human SETMAR. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | SETMAR; Histone-lysine N-methyltransferase SETMAR; SET domain and mariner transposase fusion gene-containing protein; HsMar1; Metnase |
UniProt Protein Function: | SETMAR: Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element. Has DNA nicking activity. Has in vivo end joining activity and may mediate genomic integration of foreign DNA. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine Chromosomal Location of Human Ortholog: 3p26.1 Cellular Component: condensed chromosome; nucleus Molecular Function:protein binding; structure-specific DNA binding; protein homodimerization activity; zinc ion binding; single-stranded DNA specific endodeoxyribonuclease activity; histone lysine N-methyltransferase activity (H3-K4 specific); endonuclease activity; double-stranded DNA binding; single-stranded DNA binding; transposase activity; histone lysine N-methyltransferase activity (H3-K36 specific) Biological Process: cell proliferation; DNA integration; histone H3-K4 methylation; DNA double-strand break processing; histone H3-K36 methylation; transposition, DNA-mediated; DNA catabolic process, endonucleolytic; double-strand break repair via nonhomologous end joining; replication fork processing |
NCBI Summary: | This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] |
UniProt Code: | Q53H47 |
NCBI GenInfo Identifier: | 613504379 |
NCBI Gene ID: | 6419 |
NCBI Accession: | Q53H47.2 |
UniProt Related Accession: | Q53H47 |
Molecular Weight: | 73kDa |
NCBI Full Name: | Histone-lysine N-methyltransferase SETMAR |
NCBI Synonym Full Names: | SET domain and mariner transposase fusion gene |
NCBI Official Symbol: | SETMAR |
NCBI Official Synonym Symbols: | Mar1; METNASE |
NCBI Protein Information: | histone-lysine N-methyltransferase SETMAR |
UniProt Protein Name: | Histone-lysine N-methyltransferase SETMAR |
UniProt Synonym Protein Names: | SET domain and mariner transposase fusion protein; ; |
Protein Family: | Histone-lysine N-methyltransferase |
UniProt Gene Name: | SETMAR |
UniProt Entry Name: | SETMR_HUMAN |