SERPINI1 Antibody, FITC conjugated (PACO52732)
- SKU:
- PACO52732
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | SERPINI1 Antibody, FITC conjugated (PACO52732) |
抗体コード: | PACO52732 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Neuroserpin protein (191-240AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator. |
シノニム: | Neuroserpin (Peptidase inhibitor 12) (PI-12) (Serpin I1), SERPINI1, PI12 |
UniProt Protein Function: | SERPINI1: Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator. Defects in SERPINI1 are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B). FEN1B is characterized clinically as an autosomal dominantly inherited dementia, histologically by unique neuronal inclusion bodies and biochemically by polymers of neuroserpin. Belongs to the serpin family. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 3q26.1 Cellular Component: extracellular space Molecular Function:serine-type endopeptidase inhibitor activity Biological Process: regulation of cell adhesion; central nervous system development; peripheral nervous system development Disease: Encephalopathy, Familial, With Neuroserpin Inclusion Bodies |
NCBI Summary: | This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q99574 |
NCBI GenInfo Identifier: | 3183087 |
NCBI Gene ID: | 5274 |
NCBI Accession: | Q99574.1 |
UniProt Secondary Accession: | Q99574,Q6AHZ4, A8K217, D3DNP1, |
UniProt Related Accession: | Q99574 |
Molecular Weight: | 46,427 Da |
NCBI Full Name: | Neuroserpin |
NCBI Synonym Full Names: | serpin peptidase inhibitor, clade I (neuroserpin), member 1 |
NCBI Official Symbol: | SERPINI1 |
NCBI Official Synonym Symbols: | PI12; neuroserpin |
NCBI Protein Information: | neuroserpin; PI-12; serpin I1; peptidase inhibitor 12; serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1 |
UniProt Protein Name: | Neuroserpin |
UniProt Synonym Protein Names: | Peptidase inhibitor 12; PI-12; Serpin I1 |
Protein Family: | Neuroserpin |
UniProt Gene Name: | SERPINI1 |
UniProt Entry Name: | NEUS_HUMAN |