UniProt Protein Function: | SERPINF2: Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin. Defects in SERPINF2 are the cause of alpha-2-plasmin inhibitor deficiency (APLID). APLID is an autosomal recessive disorder resulting in severe hemorrhagic diathesis. Belongs to the serpin family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 17p13 Cellular Component: extracellular space; cell surface; fibrinogen complex; extracellular region Molecular Function:serine-type endopeptidase inhibitor activity; protein binding; protein homodimerization activity; protease binding; endopeptidase inhibitor activity Biological Process: platelet activation; collagen fibril organization; positive regulation of smooth muscle cell proliferation; positive regulation of collagen biosynthetic process; positive regulation of JNK cascade; response to organic substance; fibrinolysis; negative regulation of fibrinolysis; platelet degranulation; renin-angiotensin regulation of blood vessel size; positive regulation of stress fiber formation; acute-phase response; blood vessel morphogenesis; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; positive regulation of cell differentiation Disease: Alpha-2-plasmin Inhibitor Deficiency |
NCBI Summary: | This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] |
UniProt Code: | P08697 |
NCBI GenInfo Identifier: | 260064048 |
NCBI Gene ID: | 5345 |
NCBI Accession: | NP_001159392.1 |
UniProt Secondary Accession: | P08697,Q8N5U7, Q9UCG2, Q9UCG3, B4E1B7, |
UniProt Related Accession: | P08697 |
Molecular Weight: | 47,907 Da |
NCBI Full Name: | alpha-2-antiplasmin isoform a |
NCBI Synonym Full Names: | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 |
NCBI Official Symbol: | SERPINF2 |
NCBI Official Synonym Symbols: | AAP; API; PLI; A2AP; ALPHA-2-PI |
NCBI Protein Information: | alpha-2-antiplasmin; alpha-2-AP; alpha-2-plasmin inhibitor; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2; serpin F2 |
UniProt Protein Name: | Alpha-2-antiplasmin |
UniProt Synonym Protein Names: | Alpha-2-plasmin inhibitor; Alpha-2-PI; Serpin F2 |
UniProt Gene Name: | SERPINF2 |
UniProt Entry Name: | A2AP_HUMAN |