SERPINB5 Antibody (PACO14683)
- SKU:
- PACO14683
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SERPINB5 Antibody (PACO14683) |
抗体コード: | PACO14683 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:100-1:300 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human SERPINB5 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO14683(SERPINB5 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse esophagus tissue, human cervical cancer tissue, Primary antibody: PACO14683(SERPINB5 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 13 seconds. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO14683(SERPINB5 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | Maspin (mammary serine protease inhibitor) also known as serpin B5 is a protein that in humans is encoded by the SERPINB5 gene.[1] This protein belongs to the serpin (serine protease inhibitor) superfamily.[1] SERPINB5 also functions as a tumor suppressor gene in epithelial cells. The expressed protein suppresses the ability of cancer cells to invade and metastasize other tissues. The protein also functions as an angiogenesis inhibitor.It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. |
シノニム: | serpin peptidase inhibitor, clade B (ovalbumin), member 5 |
UniProt Protein Function: | maspin: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. Interacts with IRF6. Normal mammary epithelial cells. Belongs to the serpin family. Ov-serpin subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 18q21.33 Cellular Component: extracellular space; cytoplasm Molecular Function:serine-type endopeptidase inhibitor activity; protein binding Biological Process: extracellular matrix organization and biogenesis; morphogenesis of an epithelium; cell motility; regulation of epithelial cell proliferation |
UniProt Code: | P36952 |
NCBI GenInfo Identifier: | 229462757 |
NCBI Gene ID: | 5268 |
NCBI Accession: | P36952.2 |
UniProt Secondary Accession: | P36952,Q6N0B4, Q8WW89, B2R6Y4, |
UniProt Related Accession: | P36952 |
Molecular Weight: | 25,763 Da |
NCBI Full Name: | Serpin B5 |
NCBI Synonym Full Names: | serpin peptidase inhibitor, clade B (ovalbumin), member 5 |
NCBI Official Symbol: | SERPINB5 |
NCBI Official Synonym Symbols: | PI5; maspin |
NCBI Protein Information: | serpin B5; PI-5; peptidase inhibitor 5; protease inhibitor 5 (maspin); serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5 |
UniProt Protein Name: | Serpin B5 |
UniProt Synonym Protein Names: | Maspin; Peptidase inhibitor 5; PI-5 |
Protein Family: | Serpin |
UniProt Gene Name: | SERPINB5 |
UniProt Entry Name: | SPB5_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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