SEPN1 Antibody (PACO20420)
- SKU:
- PACO20420
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SEPN1 Antibody (PACO20420) |
抗体コード: | PACO20420 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
反応性: | Human |
免疫原: | Synthetic peptide of human SEPN1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20420(SEPN1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | Gel: 8%SDS-PAGE,Lysate: 40 μgPrimary antibody: PACO20420(SEPN1 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 10 minutes. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20420(SEPN1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. |
シノニム: | selenoprotein N, 1 |
UniProt Protein Function: | SEPN1: Defects in SEPN1 are the cause of rigid spine muscular dystrophy 1 (RSMD1). A neuromuscular disorder characterized by poor axial muscle strength, scoliosis and neck weakness, and a variable degree of spinal rigidity. Early ventilatory insufficiency can lead to death by respiratory failure. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1p36.13 Cellular Component: endoplasmic reticulum membrane Molecular Function:protein binding Biological Process: calcium ion homeostasis; skeletal muscle fiber development Disease: Rigid Spine Muscular Dystrophy 1 |
NCBI Summary: | This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Mutations in this gene cause the classical phenotype of multiminicore disease and congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NZV5 |
NCBI GenInfo Identifier: | 317373588 |
NCBI Gene ID: | 57190 |
NCBI Accession: | Q9NZV5.5 |
UniProt Secondary Accession: | Q9NZV5,Q6PI70, Q969F6, Q9NUI6, A6NJG8, A8MQ64, |
UniProt Related Accession: | Q9NZV5 |
Molecular Weight: | 62,034 Da |
NCBI Full Name: | Selenoprotein N |
NCBI Synonym Full Names: | selenoprotein N, 1 |
NCBI Official Symbol: | SEPN1 |
NCBI Official Synonym Symbols: | RSS; CFTD; SELN; MDRS1; RSMD1 |
NCBI Protein Information: | selenoprotein N |
UniProt Protein Name: | Selenoprotein N |
Protein Family: | Selenoprotein |
UniProt Gene Name: | SEPN1 |
UniProt Entry Name: | SELN_HUMAN |
Antibodies |
Anti-SEPN1 Antibody (CAB15012) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |