SELPLG Antibody (PACO21178)
- SKU:
- PACO21178
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SELPLG Antibody (PACO21178) |
抗体コード: | PACO21178 |
サイズ: | 100ul(100ug) |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant protein of human SELPLG |
憲法: | Liquid |
ストレージバッファ: | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot analysis of extracts of Jurkat cell lines, using SELPLG antibody. |
バックグラウンド: | This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants. |
シノニム: | SELPLG; CLA; CD162; PSGL1; PSGL-1 |
UniProt Protein Function: | SELPLG: A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 12q24 Cellular Component: membrane; integral to plasma membrane; plasma membrane; integral to membrane Molecular Function:protein binding; receptor binding Biological Process: leukocyte tethering or rolling; cell adhesion; blood coagulation; leukocyte adhesive activation; leukocyte migration |
NCBI Summary: | This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011] |
UniProt Code: | Q14242 |
NCBI GenInfo Identifier: | 2498904 |
NCBI Gene ID: | 6404 |
NCBI Accession: | Q14242.1 |
UniProt Secondary Accession: | Q14242,Q12775, Q6GTW7, Q8N7J7, A8K2Y0, B4DQC3, B7Z5C7 J3KMX6, |
UniProt Related Accession: | Q14242 |
Molecular Weight: | 412 |
NCBI Full Name: | P-selectin glycoprotein ligand 1 |
NCBI Synonym Full Names: | selectin P ligand |
NCBI Official Symbol: | SELPLG |
NCBI Official Synonym Symbols: | CLA; CD162; PSGL1; PSGL-1 |
NCBI Protein Information: | P-selectin glycoprotein ligand 1; cutaneous lymphocyte-associated associated antigen |
UniProt Protein Name: | P-selectin glycoprotein ligand 1 |
UniProt Synonym Protein Names: | Selectin P ligand; CD_antigen: CD162 |
Protein Family: | P-selectin glycoprotein ligand |
UniProt Gene Name: | SELPLG |
UniProt Entry Name: | SELPL_HUMAN |