SEL1L Antibody, Biotin conjugated (PACO57455)
- SKU:
- PACO57455
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | SEL1L Antibody, Biotin conjugated (PACO57455) |
抗体コード: | PACO57455 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Protein sel-1 homolog 1 protein (22-181AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling. |
シノニム: | Protein sel-1 homolog 1 (Suppressor of lin-12-like protein 1) (Sel-1L), SEL1L, TSA305 |
UniProt Protein Function: | SEL1L: May play a role in Notch signaling. May be involved in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Belongs to the sel-1 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 14q31 Cellular Component: endoplasmic reticulum membrane Molecular Function:protein binding Biological Process: ER-associated protein catabolic process; protein stabilization; retrograde protein transport, ER to cytosol |
NCBI Summary: | The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
UniProt Code: | Q9UBV2 |
NCBI GenInfo Identifier: | 62512184 |
NCBI Gene ID: | 6400 |
NCBI Accession: | Q9UBV2.3 |
UniProt Secondary Accession: | Q9UBV2,Q6UWT6, Q9P1T9, Q9UHK7, |
UniProt Related Accession: | Q9UBV2 |
Molecular Weight: | 33,530 Da |
NCBI Full Name: | Protein sel-1 homolog 1 |
NCBI Synonym Full Names: | SEL1L ERAD E3 ligase adaptor subunit |
NCBI Official Symbol: | SEL1L |
NCBI Official Synonym Symbols: | SEL1L1; PRO1063; SEL1-LIKE |
NCBI Protein Information: | protein sel-1 homolog 1 |
UniProt Protein Name: | Protein sel-1 homolog 1 |
UniProt Synonym Protein Names: | Suppressor of lin-12-like protein 1; Sel-1L |
Protein Family: | Protein |
UniProt Gene Name: | SEL1L |
UniProt Entry Name: | SE1L1_HUMAN |