SEC63 Antibody (PACO12089)
- SKU:
- PACO12089
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SEC63 Antibody (PACO12089) |
抗体コード: | PACO12089 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human SEC63 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | SEC63 homolog (S. cerevisiae);SEC63;ERdj2;PRO2507;SEC63L ; |
UniProt Protein Function: | SEC63: Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane. Defects in SEC63 are a cause of polycystic liver disease (PCLD). PCLD is an autosomal dominant disorder and is characterized by the presence of multiple liver cysts of biliary epithelial origin.Protein type: Membrane protein, integral; Endoplasmic reticulum; Membrane protein, multi-passChromosomal Location of Human Ortholog: 6q21Cellular Component: cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; membraneMolecular Function: protein binding; receptor activityBiological Process: posttranslational protein targeting to membrane; protein targeting to membrane; SRP-dependent cotranslational protein targeting to membraneDisease: Polycystic Liver Disease |
UniProt Protein Details: | |
NCBI Summary: | The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UGP8 |
NCBI GenInfo Identifier: | 18203500 |
NCBI Gene ID: | 11231 |
NCBI Accession: | Q9UGP8.2 |
UniProt Secondary Accession: | Q9UGP8,O95380, Q5THN4, Q86VS9, Q8IWL0, Q9NTE0 |
UniProt Related Accession: | Q9UGP8 |
Molecular Weight: | 87,997 Da |
NCBI Full Name: | Translocation protein SEC63 homolog |
NCBI Synonym Full Names: | SEC63 homolog, protein translocation regulator |
NCBI Official Symbol: | SEC63 |
NCBI Official Synonym Symbols: | ERdj2; SEC63L; DNAJC23; PRO2507 |
NCBI Protein Information: | translocation protein SEC63 homolog |
UniProt Protein Name: | Translocation protein SEC63 homolog |
UniProt Synonym Protein Names: | |
Protein Family: | Translocation protein |
UniProt Gene Name: | SEC63 |
UniProt Entry Name: | SEC63_HUMAN |