SCIN Antibody (PACO49042)
- SKU:
- PACO49042
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SCIN Antibody (PACO49042) |
抗体コード: | PACO49042 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IF:1:50-1:500 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human Adseverin protein (556-703AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: Mouse stomach tissue. All lanes: SCIN antibody at 3.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 81, 66, 53 kDa. Observed band size: 81 kDa.. |
![]() | Immunofluorescent analysis of HepG2 cells using PACO49042 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes (By similarity). |
シノニム: | Adseverin (Scinderin), SCIN, KIAA1905 |
UniProt Protein Function: | SCIN: Ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes. Belongs to the villin/gelsolin family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 7p21.3 Cellular Component: protein complex; cytoskeleton; cytoplasm; cell cortex Molecular Function:actin filament binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; calcium ion binding; actin binding; phosphatidylinositol binding Biological Process: negative regulation of cell proliferation; actin filament severing; positive regulation of apoptosis; actin filament capping; positive regulation of secretion; positive regulation of megakaryocyte differentiation; regulation of chondrocyte differentiation; actin nucleation; calcium ion-dependent exocytosis |
NCBI Summary: | SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]).[supplied by OMIM, May 2010] |
UniProt Code: | Q9Y6U3 |
NCBI GenInfo Identifier: | 57015325 |
NCBI Gene ID: | 85477 |
NCBI Accession: | Q9Y6U3.4 |
UniProt Secondary Accession: | Q9Y6U3,Q8NBZ6, Q8WU97, Q96JC7, Q96PY2, A8K2U8, |
UniProt Related Accession: | Q9Y6U3 |
Molecular Weight: | 715 |
NCBI Full Name: | Adseverin |
NCBI Synonym Full Names: | scinderin |
NCBI Official Symbol: | SCIN |
NCBI Protein Information: | adseverin |
UniProt Protein Name: | Adseverin |
UniProt Synonym Protein Names: | Scinderin |
Protein Family: | Adseverin |
UniProt Gene Name: | SCIN |
UniProt Entry Name: | ADSV_HUMAN |