RPS6KA6 Antibody (PACO56234)
- SKU:
- PACO56234
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | RPS6KA6 Antibody (PACO56234) |
抗体コード: | PACO56234 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
反応性: | Human |
免疫原: | Recombinant Human Ribosomal protein S6 kinase alpha-6 protein (340-467AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | IHC image of PACO56234 diluted at 1:400 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
バックグラウンド: | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. |
シノニム: | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4), RPS6KA6, RSK4 |
UniProt Protein Function: | RSK4: an AGC kinase of the RSK family. Phosphorylates a wide range of substrates including ribosomal protein S6. Implicated in the activation of the mitogen- activated kinase cascade. May play a role in normal neuronal development. |
UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; AGC group; RSK family; RSK subfamily Chromosomal Location of Human Ortholog: Xq21 Cellular Component: cytoplasm; cytosol; mitochondrion; nucleolus; nucleoplasm; nucleus Molecular Function:kinase activity; protein kinase activity; protein serine/threonine kinase activity Biological Process: central nervous system development; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; negative regulation of embryonic development; signal transduction |
NCBI Summary: | This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010] |
UniProt Code: | Q9UK32 |
NCBI GenInfo Identifier: | 11133131 |
NCBI Gene ID: | 27330 |
NCBI Accession: | Q9UK32.1 |
UniProt Secondary Accession: | Q9UK32,Q6FHX2, Q8WX28, Q9H4S6, B2R854, B7ZL90, |
UniProt Related Accession: | Q9UK32 |
Molecular Weight: | 84,093 Da |
NCBI Full Name: | Ribosomal protein S6 kinase alpha-6 |
NCBI Synonym Full Names: | ribosomal protein S6 kinase A6 |
NCBI Official Symbol: | RPS6KA6 |
NCBI Official Synonym Symbols: | RSK4; PP90RSK4 |
NCBI Protein Information: | ribosomal protein S6 kinase alpha-6 |
UniProt Protein Name: | Ribosomal protein S6 kinase alpha-6 |
UniProt Synonym Protein Names: | 90 kDa ribosomal protein S6 kinase 6; p90-RSK 6; p90RSK6; Ribosomal S6 kinase 4; RSK-4; pp90RSK4 |
Protein Family: | Ribosomal protein S6 kinase |
UniProt Gene Name: | RPS6KA6 |
UniProt Entry Name: | KS6A6_HUMAN |