UniProt Protein Function: | Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. |
NCBI Summary: | This gene encodes a cell-cycle and transcription regulatory protein. The encoded protein interacts with the cell cycle inhibitor cyclin-dependent kinase 4 inhibitor B and may function as a negative regulator of G(1)/S phase progression. This protein also forms homo- and hetrodimers with the protein, regulation of nuclear pre-mRNA domain-containing protein 1B, to form a scaffold that interacts with the C-terminal domain of RNA polymerase II subunit B1 and regulates several aspects of transcription. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 16. [provided by RefSeq, Dec 2014] |
UniProt Code: | Q96P16 |
NCBI GenInfo Identifier: | 21361709 |
NCBI Gene ID: | 55197 |
NCBI Accession: | NP_060640 |
UniProt Secondary Accession: | Q96P16,Q7Z5G8, Q96FY9, Q9NVL4, A8KA42, B2RBA3, |
UniProt Related Accession: | Q96P16 |
Molecular Weight: | 38.4kDa (337aa) confirmed by MALDI-TOF |
NCBI Full Name: | regulation of nuclear pre-mRNA domain-containing protein 1A isoform 1 |
NCBI Synonym Full Names: | regulation of nuclear pre-mRNA domain containing 1A |
NCBI Official Symbol: | RPRD1A |
NCBI Official Synonym Symbols: | P15RS; HsT3101 |
NCBI Protein Information: | regulation of nuclear pre-mRNA domain-containing protein 1A |
UniProt Protein Name: | Regulation of nuclear pre-mRNA domain-containing protein 1A |
UniProt Synonym Protein Names: | Cyclin-dependent kinase inhibitor 2B-related protein; p15INK4B-related protein |
UniProt Gene Name: | RPRD1A |