ROS1 Antibody, Biotin conjugated (PACO62366)
- SKU:
- PACO62366
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | ROS1 Antibody, Biotin conjugated (PACO62366) |
抗体コード: | PACO62366 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Proto-oncogene tyrosine-protein kinase ROS protein (79-248AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. |
シノニム: | Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase), ROS1, MCF3 ROS |
UniProt Protein Function: | ROS: a proto-oncogenic receptor tyrosine kinase whose expression is tightly restricted during development. Normally expressed in adult murine and human epithelial cells of the epididymis. Transgenic mice lacking the c-ros gene are infertile. Ectopic expression of c-Ros has been reported in meningiomas and astrocytomas. Is up-regulated in human glioma: 30% of malignant glioma tumors are ROS positive. An oncogenic fusion protein between PIST (aka FIG) and ROS, resulting from an intra-chromosomal homozygous deletion of 240 kilobases on 6q21, is found in glioblastoma multiform. PIST (aka FIG) is a peripheral membrane protein associated with the Golgi apparatus. Unlike other fusion RTK oncogenes, the mechanism of activation of PIST-ROS does not appear to be dimerization: the PIST-ROS fusion protein appears to be monomeric in vivo. Rather, activation of the fused ROS kinase appears to depend upon translocation to the golgi apparatus: deletion of 2nd coiled-coil region of PIST, crucial for Golgi localization, appears to eliminate the transformation capacity of PIST-ROS. c-ROS may also be activated epigenetically, suggesting caution when using 5-aza-dC for treating glioma. |
UniProt Protein Details: | Protein type:Kinase, protein; Membrane protein, integral; Protein kinase, TK; Oncoprotein; Protein kinase, tyrosine (receptor); EC 2.7.10.1; TK group; Sev family Chromosomal Location of Human Ortholog: 6q22 Cellular Component: membrane Molecular Function:protein binding; protein phosphatase binding; protein-tyrosine kinase activity Biological Process: cell differentiation; cell growth; cell proliferation; columnar/cuboidal epithelial cell development; protein amino acid phosphorylation; regulation of TOR signaling pathway; spermatogenesis |
NCBI Summary: | This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008] |
UniProt Code: | P08922 |
NCBI GenInfo Identifier: | 126302596 |
NCBI Gene ID: | 6098 |
NCBI Accession: | P08922.3 |
UniProt Secondary Accession: | P08922,Q15368, Q5TDB5, |
UniProt Related Accession: | P08922 |
Molecular Weight: | 263,915 Da |
NCBI Full Name: | Proto-oncogene tyrosine-protein kinase ROS |
NCBI Synonym Full Names: | ROS proto-oncogene 1, receptor tyrosine kinase |
NCBI Official Symbol: | ROS1 |
NCBI Official Synonym Symbols: | ROS; MCF3; c-ros-1 |
NCBI Protein Information: | proto-oncogene tyrosine-protein kinase ROS |
UniProt Protein Name: | Proto-oncogene tyrosine-protein kinase ROS |
UniProt Synonym Protein Names: | Proto-oncogene c-Ros; Proto-oncogene c-Ros-1; Receptor tyrosine kinase c-ros oncogene 1; c-Ros receptor tyrosine kinase |
Protein Family: | Rosmarinate synthase |
UniProt Gene Name: | ROS1 |
UniProt Entry Name: | ROS1_HUMAN |