RORB Antibody, FITC conjugated (PACO63829)
- SKU:
- PACO63829
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | RORB Antibody, FITC conjugated (PACO63829) |
抗体コード: | PACO63829 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Nuclear receptor ROR-β protein (1-269AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid, (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity). |
シノニム: | Nuclear receptor ROR-β (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta), RORB, NR1F2 RZRB |
UniProt Protein Function: | RORB: Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells. Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5'-AGGTCA-3' in the OPN1SW promoter. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: DNA-binding; Nuclear receptorChromosomal Location of Human Ortholog: 9q22Cellular Component: nucleoplasm; nucleusMolecular Function: ligand-dependent nuclear receptor activity; protein binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription factor activity; transcription factor bindingBiological Process: transcription initiation from RNA polymerase II promoter; retinal rod cell development; intracellular receptor-mediated signaling pathway; positive regulation of transcription, DNA-dependent; rhythmic process; regulation of circadian rhythm; eye photoreceptor cell development; regulation of transcription, DNA-dependent; visual perception; retinal cone cell development; retina development in camera-type eye; negative regulation of osteoblast differentiation; gene expression; steroid hormone mediated signaling; negative regulation of transcription, DNA-dependent |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014] |
UniProt Code: | Q92753 |
NCBI GenInfo Identifier: | 124028630 |
NCBI Gene ID: | 124028630 |
NCBI Accession: | Q92753.3 |
UniProt Secondary Accession: | Q92753,Q8WX73 |
UniProt Related Accession: | Q92753 |
Molecular Weight: | 53220 |
NCBI Full Name: | Nuclear receptor ROR-beta |
NCBI Synonym Full Names: | |
NCBI Official Symbol: | |
NCBI Official Synonym Symbols: | |
NCBI Protein Information: | |
UniProt Protein Name: | Nuclear receptor ROR-beta |
UniProt Synonym Protein Names: | Nuclear receptor RZR-beta; Nuclear receptor subfamily 1 group F member 2; Retinoid-related orphan receptor-beta |
Protein Family: | Nuclear receptor |
UniProt Gene Name: | RORB |
UniProt Entry Name: | RORB_HUMAN |