UniProt Protein Function: | ROR1: Tyrosine-protein kinase receptor whose role is not yet clear. Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 2.7.10.1; Protein kinase, tyrosine (receptor); Membrane protein, integral; Protein kinase, TK; Kinase, protein; TK group; Ror family Chromosomal Location of Human Ortholog: 1p31.3 Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; receptor complex Molecular Function:Wnt-protein binding; protein binding; transmembrane receptor protein tyrosine kinase activity; ATP binding Biological Process: peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway |
NCBI Summary: | This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012] |
UniProt Code: | Q01973 |
NCBI GenInfo Identifier: | 118572711 |
NCBI Gene ID: | 4919 |
NCBI Accession: | Q01973.2 |
UniProt Secondary Accession: | Q01973,Q5VVX6, Q66K77, Q92776, |
UniProt Related Accession: | Q01973 |
Molecular Weight: | 937 |
NCBI Full Name: | Tyrosine-protein kinase transmembrane receptor ROR1 |
NCBI Synonym Full Names: | receptor tyrosine kinase-like orphan receptor 1 |
NCBI Official Symbol: | ROR1 |
NCBI Official Synonym Symbols: | NTRKR1; dJ537F10.1 |
NCBI Protein Information: | tyrosine-protein kinase transmembrane receptor ROR1; neurotrophic tyrosine kinase, receptor-related 1 |
UniProt Protein Name: | Tyrosine-protein kinase transmembrane receptor ROR1 |
UniProt Synonym Protein Names: | Neurotrophic tyrosine kinase, receptor-related 1 |
Protein Family: | Inactive tyrosine-protein kinase transmembrane receptor |
UniProt Gene Name: | ROR1 |
UniProt Entry Name: | ROR1_HUMAN |