RNF7 Antibody (PACO16994)
- SKU:
- PACO16994
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | RNF7 Antibody (PACO16994) |
抗体コード: | PACO16994 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:10-1:50 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human RNF7 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue, Primary antibody: PACO16994(RNF7 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16994(RNF7 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBα (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). |
シノニム: | ring finger protein 7 |
UniProt Protein Function: | RNF7: a highly conserved ring finger protein. An essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. The RING-type zinc finger recruits the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. This protein interacts with, and is a substrate of, casein kinase II (CKII). The phosphorylation of this protein by CKII has been shown to promote the degradation of IkappaB-alpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Two alternatively spliced isoforms have been reported. |
UniProt Protein Details: | Protein type:EC 6.3.2.-; Ligase; Motility/polarity/chemotaxis; Ubiquitin conjugating system; Ubiquitin ligase Chromosomal Location of Human Ortholog: 3q23 Cellular Component: Cul5-RING ubiquitin ligase complex; cytosol; nucleoplasm Molecular Function:copper ion binding; NEDD8 ligase activity; protein binding Biological Process: protein neddylation; response to redox state |
NCBI Summary: | The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UBF6 |
NCBI GenInfo Identifier: | 37538003 |
NCBI Gene ID: | 9616 |
NCBI Accession: | Q9UBF6.1 |
UniProt Secondary Accession: | Q9UBF6,Q9BXN8, Q9Y5M7, A8K1H9, A8MTB5, C9JYL3, D3DNF7 D3DNF8, |
UniProt Related Accession: | Q9UBF6 |
Molecular Weight: | 10,876 Da |
NCBI Full Name: | RING-box protein 2 |
NCBI Synonym Full Names: | ring finger protein 7 |
NCBI Official Symbol: | RNF7 |
NCBI Official Synonym Symbols: | SAG; ROC2; CKBBP1 |
NCBI Protein Information: | RING-box protein 2 |
UniProt Protein Name: | RING-box protein 2 |
UniProt Synonym Protein Names: | CKII beta-binding protein 1; CKBBP1; RING finger protein 7; Regulator of cullins 2; Sensitive to apoptosis gene protein |
UniProt Gene Name: | RNF7 |
Antibodies | ELISA Kits |
Anti-RNF7 Antibody (CAB7301) | Human Rbx2(RNF7) ELISA Kit |
RNF7 Antibody (PACO11877) | Human SAG (S Antigen) ELISA Kit (HUES02064) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |