RNF5 Antibody (PACO20343)
- SKU:
- PACO20343
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | RNF5 Antibody (PACO20343) |
抗体コード: | PACO20343 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthetic peptide of human RNF5 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO20343(RNF5 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | Gel: 10%SDS-PAGE, Lysate: 40 µg, Lane 1-5: K562 cells, 231 cells, Jurkat cells, hela cells, 293T cells, Primary antibody: PACO20343(RNF5 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20343(RNF5 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. |
シノニム: | ring finger protein 5, E3 ubiquitin protein ligase |
UniProt Protein Function: | RNF5: Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and regulates antiviral responses. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Ubiquitin conjugating system; Ligase; EC 6.3.2.-; EC 6.3.2.19; Ubiquitin ligase; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 6p21.3 Molecular Function:protein binding; ubiquitin-protein ligase activity Biological Process: cellular protein catabolic process |
NCBI Summary: | The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q99942 |
NCBI GenInfo Identifier: | 74762702 |
NCBI Gene ID: | 6048 |
NCBI Accession: | Q99942.1 |
UniProt Secondary Accession: | Q99942,Q0VDB7, Q9UMQ2, A2BFI6, B2R4K3, |
UniProt Related Accession: | Q99942 |
Molecular Weight: | 19,881 Da |
NCBI Full Name: | E3 ubiquitin-protein ligase RNF5 |
NCBI Synonym Full Names: | ring finger protein 5 |
NCBI Official Symbol: | RNF5 |
NCBI Official Synonym Symbols: | RMA1; RING5 |
NCBI Protein Information: | E3 ubiquitin-protein ligase RNF5 |
UniProt Protein Name: | E3 ubiquitin-protein ligase RNF5 |
UniProt Synonym Protein Names: | Protein G16; RING finger protein 5; Ram1 homolog; HsRma1 |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | RNF5 |
UniProt Entry Name: | RNF5_HUMAN |
Antibodies |
Anti-RNF5 Antibody (CAB8351) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |