RNF4 Antibody, HRP conjugated (PACO46171)
- SKU:
- PACO46171
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | RNF4 Antibody, HRP conjugated (PACO46171) |
抗体コード: | PACO46171 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human E3 ubiquitin-protein ligase RNF4 protein (1-103AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation. |
シノニム: | E3 ubiquitin-protein ligase RNF4 (EC 2.3.2.27) (RING finger protein 4) (RING-type E3 ubiquitin transferase RNF4) (Small nuclear ring finger protein) (Protein SNURF), RNF4, SNURF |
UniProt Protein Function: | RNF4: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor- mediated transcriptional activation. |
UniProt Protein Details: | Protein type:EC 6.3.2.-; Ligase; Nuclear receptor co-regulator; Transcription factor; Ubiquitin conjugating system; Ubiquitin ligase Chromosomal Location of Human Ortholog: 4p16.3 Cellular Component: cytoplasm; nucleoplasm; nucleus; PML body Molecular Function:DNA binding; identical protein binding; nucleosome binding; protein binding; SUMO polymer binding; transcription factor activity; ubiquitin-protein ligase activity Biological Process: positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; proteasomal ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein ubiquitination; response to arsenic |
NCBI Summary: | The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.[provided by RefSeq, Jul 2010] |
UniProt Code: | P78317 |
NCBI GenInfo Identifier: | 18202358 |
NCBI Gene ID: | 6047 |
NCBI Accession: | P78317.1 |
UniProt Secondary Accession: | P78317,Q49AR8, B2R6D6, D6RF58, |
UniProt Related Accession: | P78317 |
Molecular Weight: | 21kDa |
NCBI Full Name: | E3 ubiquitin-protein ligase RNF4 |
NCBI Synonym Full Names: | ring finger protein 4 |
NCBI Official Symbol: | RNF4 |
NCBI Official Synonym Symbols: | SLX5; SNURF; RES4-26 |
NCBI Protein Information: | E3 ubiquitin-protein ligase RNF4 |
UniProt Protein Name: | E3 ubiquitin-protein ligase RNF4 |
UniProt Synonym Protein Names: | RING finger protein 4; RING-type E3 ubiquitin transferase RNF4Curated; Small nuclear ring finger protein; Protein SNURF |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | RNF4 |