RNF34 Antibody (PACO44883)
- SKU:
- PACO44883
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | RNF34 Antibody (PACO44883) |
抗体コード: | PACO44883 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human E3 ubiquitin-protein ligase RNF34 protein (1-220AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human prostate cancer using PACO44883 at dilution of 1:100. |
バックグラウンド: | E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells. Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation. |
シノニム: | E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF) (RING-type E3 ubiquitin transferase RNF34), RNF34 |
UniProt Protein Function: | RNF34: Has E3 ubiquitin-protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Protects cells against apoptosis induced by TNF. Binds phosphatidylinositol 5-phosphate and phosphatidylinositol 3- phosphate. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Ligase; Ubiquitin ligase; EC 6.3.2.- Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane Molecular Function:p53 binding; protein binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process |
NCBI Summary: | The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012] |
UniProt Code: | Q969K3 |
NCBI GenInfo Identifier: | 74760679 |
NCBI Gene ID: | 80196 |
NCBI Accession: | Q969K3.1 |
UniProt Secondary Accession: | Q969K3,Q8NG47, Q9H6W8, B7Z933, |
UniProt Related Accession: | Q969K3 |
Molecular Weight: | 41,797 Da |
NCBI Full Name: | E3 ubiquitin-protein ligase RNF34 |
NCBI Synonym Full Names: | ring finger protein 34 |
NCBI Official Symbol: | RNF34 |
NCBI Official Synonym Symbols: | RFI; RIF; RIFF; hRFI; CARP1; CARP-1 |
NCBI Protein Information: | E3 ubiquitin-protein ligase RNF34 |
UniProt Protein Name: | E3 ubiquitin-protein ligase RNF34 |
UniProt Synonym Protein Names: | Caspase regulator CARP1 |
UniProt Gene Name: | RNF34 |
UniProt Entry Name: | RNF34_HUMAN |