RNF111 Antibody (PACO04658)
- SKU:
- PACO04658
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | RNF111 Antibody |
抗体コード: | PACO04658 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | WB:1:500-1:2000 |
反応性: | Human, Mouse |
免疫原: | synthesized peptide derived from the C-terminal region of human Arkadia. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | RNF111; E3 ubiquitin-protein ligase Arkadia; RING finger protein 111 |
UniProt Protein Function: | RNF111: Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin- protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ligase; Ubiquitin ligase; EC 6.3.2.-; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 15q21 Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus Molecular Function:protein binding; SUMO polymer binding Biological Process: positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; ubiquitin-dependent SMAD protein catabolic process |
NCBI Summary: | The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012] |
UniProt Code: | Q6ZNA4 |
NCBI GenInfo Identifier: | 308153555 |
NCBI Gene ID: | 54778 |
NCBI Accession: | Q6ZNA4.3 |
UniProt Secondary Accession: | Q6ZNA4,Q6P9A4, Q6ZMU2, Q7L428, Q7Z346, Q8N1P9, Q8WUA3 Q9NSR1, C9JUS4, H0YN55, |
UniProt Related Accession: | Q6ZNA4 |
Molecular Weight: | 108,906 Da |
NCBI Full Name: | E3 ubiquitin-protein ligase Arkadia |
NCBI Synonym Full Names: | ring finger protein 111 |
NCBI Official Symbol: | RNF111 |
NCBI Official Synonym Symbols: | ARK |
NCBI Protein Information: | E3 ubiquitin-protein ligase Arkadia |
UniProt Protein Name: | E3 ubiquitin-protein ligase Arkadia |
UniProt Synonym Protein Names: | RING finger protein 111 |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | RNF111 |
UniProt Entry Name: | RN111_HUMAN |