RIT1 Antibody, FITC conjugated (PACO39252)
- SKU:
- PACO39252
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | RIT1 Antibody, FITC conjugated (PACO39252) |
抗体コード: | PACO39252 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human GTP-binding protein Rit1 protein (1-219AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation. |
シノニム: | GTP-binding protein Rit1 (Ras-like protein expressed in many tissues) (Ras-like without CAAX protein 1), RIT1, RIBB RIT ROC1 |
UniProt Protein Function: | RIT1: a small G protein of the Ras family. Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and p38-alpha signaling pathways and in NGF- dependent neuronal differentiation. Stimulation of the NGF and EGF receptor signaling pathways results in rapid and prolonged activation. Interacts with afadin, the C-terminal domain of RalGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form. Strongly interacts with BRAF, but only weakly with c-Raf. BRAF and c-RAF association is dependent upon the GTP-bound state. Interacts with RGL3. Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members. |
UniProt Protein Details: | Protein type:G protein, monomeric, Ras; G protein; G protein, monomeric Chromosomal Location of Human Ortholog: 1q22 Molecular Function:calmodulin binding; protein binding Biological Process: Ras protein signal transduction; signal transduction Disease: Noonan Syndrome 8 |
NCBI Summary: | This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38 MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] |
UniProt Code: | Q92963 |
NCBI GenInfo Identifier: | 38258628 |
NCBI Gene ID: | 6016 |
NCBI Accession: | Q92963.1 |
UniProt Secondary Accession: | Q92963,O00646, O00720, Q5VY89, Q5VY90, B4DQE8, |
UniProt Related Accession: | Q92963 |
Molecular Weight: | 27,148 Da |
NCBI Full Name: | GTP-binding protein Rit1 |
NCBI Synonym Full Names: | Ras like without CAAX 1 |
NCBI Official Symbol: | RIT1 |
NCBI Official Synonym Symbols: | NS8; RIT; RIBB; ROC1 |
NCBI Protein Information: | GTP-binding protein Rit1 |
UniProt Protein Name: | GTP-binding protein Rit1 |
UniProt Synonym Protein Names: | Ras-like protein expressed in many tissues; Ras-like without CAAX protein 1 |
Protein Family: | GTP-binding protein |
UniProt Gene Name: | RIT1 |
UniProt Entry Name: | RIT1_HUMAN |