RGS4 Antibody (PACO16970)
- SKU:
- PACO16970
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | RGS4 Antibody (PACO16970) |
抗体コード: | PACO16970 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
反応性: | Human, Mouse, Rat |
免疫原: | Fusion protein of human RGS4 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO16970(RGS4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G α subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go α and Gq α subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid, sequence termed the RGS domain. |
シノニム: | regulator of G-protein signaling 4 |
UniProt Protein Function: | RGS4: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex. Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:GAPs, RGS; GAPs Chromosomal Location of Human Ortholog: 1q23.3 Cellular Component: cytoplasm; nucleus; plasma membrane Molecular Function:calmodulin binding Biological Process: inactivation of MAPK activity; regulation of G-protein coupled receptor protein signaling pathway Disease: Schizophrenia 9 |
NCBI Summary: | Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P49798 |
NCBI GenInfo Identifier: | 1710146 |
NCBI Gene ID: | 5999 |
NCBI Accession: | P49798.1 |
UniProt Secondary Accession: | P49798,A7XA56, A7XA58, A7XA59, A7YVV7, B1APZ3, |
UniProt Related Accession: | P49798 |
Molecular Weight: | 21,452 Da |
NCBI Full Name: | Regulator of G-protein signaling 4 |
NCBI Synonym Full Names: | regulator of G-protein signaling 4 |
NCBI Official Symbol: | RGS4 |
NCBI Official Synonym Symbols: | RGP4; SCZD9 |
NCBI Protein Information: | regulator of G-protein signaling 4 |
UniProt Protein Name: | Regulator of G-protein signaling 4 |
Protein Family: | Regulator of G-protein signaling |
UniProt Gene Name: | RGS4 |
UniProt Entry Name: | RGS4_HUMAN |
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