RGS10 Antibody (PACO45536)
- SKU:
- PACO45536
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | RGS10 Antibody (PACO45536) |
抗体コード: | PACO45536 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Regulator of G-protein signaling 10 protein (1-181AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO45536 at dilution of 1:100. |
バックグラウンド: | Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein α subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to CHRM2 signaling. Activity on GNAZ is inhibited by palmitoylation of the G-protein. |
シノニム: | Regulator of G-protein signaling 10 (RGS10), RGS10 |
UniProt Protein Function: | RGS10: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)- alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein. |
UniProt Protein Details: | Protein type:GAPs, RGS; GAPs Chromosomal Location of Human Ortholog: 10q25 Cellular Component: cell soma; cytoplasm; dendritic spine; plasma membrane; nerve terminal; nucleus Molecular Function:GTPase activator activity Biological Process: positive regulation of GTPase activity |
NCBI Summary: | Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | O43665 |
NCBI GenInfo Identifier: | 52694755 |
NCBI Gene ID: | 6001 |
NCBI Accession: | NP_001005339.1 |
UniProt Secondary Accession: | O43665,Q6IAZ6, Q96GN0, A8K408, B1AMR8, |
UniProt Related Accession: | O43665 |
Molecular Weight: | 20 KD |
NCBI Full Name: | regulator of G-protein signaling 10 isoform a |
NCBI Synonym Full Names: | regulator of G-protein signaling 10 |
NCBI Official Symbol: | RGS10 |
NCBI Protein Information: | regulator of G-protein signaling 10; regulator of G-protein signalling 10 |
UniProt Protein Name: | Regulator of G-protein signaling 10 |
Protein Family: | Regulator of G-protein signaling |
UniProt Gene Name: | RGS10 |
UniProt Entry Name: | RGS10_HUMAN |
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