RFC2 Antibody (PACO19188)
- SKU:
- PACO19188
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | RFC2 Antibody (PACO19188) |
抗体コード: | PACO19188 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
反応性: | Human |
免疫原: | Synthetic peptide of human RFC2 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Gel: 10%SDS-PAGE,Lysate: 40 μg,,Primary antibody: PACO19188(RFC2 Antibody) at dilution 1/500 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 20 seconds. |
バックグラウンド: | This gene encodes a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Replication factor C, also called activator 1, is a protein complex consisting of five distinct subunits. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP and may help promote cell survival. Disruption of this gene is associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene of this gene has been defined on chromosome 2. |
シノニム: | replication factor C (activator 1) 2, 40kDa |
UniProt Protein Function: | RFC2: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP. RFC2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Belongs to the activator 1 small subunits family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA replication Chromosomal Location of Human Ortholog: 7q11.23 Cellular Component: DNA replication factor C complex; nucleoplasm Molecular Function:DNA clamp loader activity; protein binding; single-stranded DNA-dependent ATPase activity Biological Process: bypass DNA synthesis; DNA damage response, detection of DNA damage; DNA replication; error-prone postreplication DNA repair; nucleotide-excision repair, DNA gap filling; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 5'-to lesion; telomere maintenance via recombination; transcription-coupled nucleotide-excision repair |
NCBI Summary: | This gene encodes a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Replication factor C, also called activator 1, is a protein complex consisting of five distinct subunits. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP and may help promote cell survival. Disruption of this gene is associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene of this gene has been defined on chromosome 2. [provided by RefSeq, Jul 2013] |
UniProt Code: | P35250 |
NCBI GenInfo Identifier: | 2507300 |
NCBI Gene ID: | 5982 |
NCBI Accession: | P35250.3 |
UniProt Secondary Accession: | P35250,P32846, Q9BU93, B5BU07, D3DXG3, |
UniProt Related Accession: | P35250 |
Molecular Weight: | 35,244 Da |
NCBI Full Name: | Replication factor C subunit 2 |
NCBI Synonym Full Names: | replication factor C subunit 2 |
NCBI Official Symbol: | RFC2 |
NCBI Official Synonym Symbols: | RFC40 |
NCBI Protein Information: | replication factor C subunit 2 |
UniProt Protein Name: | Replication factor C subunit 2 |
UniProt Synonym Protein Names: | Activator 1 40 kDa subunit; A1 40 kDa subunit; Activator 1 subunit 2; Replication factor C 40 kDa subunit; RF-C 40 kDa subunit; RFC40 |
Protein Family: | Replication factor |
UniProt Gene Name: | RFC2 |
UniProt Entry Name: | RFC2_HUMAN |