UniProt Protein Function: | RERE: Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. A chromosomal aberration involving RERE is found in the neuroblastoma cell line. Translocation t(1;15)(p36.2;q24). 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription factor; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 1p36.23 Molecular Function:poly-glutamine tract binding; protein binding Biological Process: NLS-bearing substrate import into nucleus |
NCBI Summary: | This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9P2R6 |
NCBI GenInfo Identifier: | 85540730 |
NCBI Gene ID: | 473 |
NCBI Accession: | Q9P2R6.2 |
UniProt Secondary Accession: | Q9P2R6,O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4 |
UniProt Related Accession: | Q9P2R6 |
Molecular Weight: | 109,048 Da |
NCBI Full Name: | Arginine-glutamic acid dipeptide repeats protein |
NCBI Synonym Full Names: | arginine-glutamic acid dipeptide repeats |
NCBI Official Symbol: | RERE |
NCBI Official Synonym Symbols: | ARG; ARP; DNB1; ATN1L; NEDBEH |
NCBI Protein Information: | arginine-glutamic acid dipeptide repeats protein |
UniProt Protein Name: | Arginine-glutamic acid dipeptide repeats protein |
UniProt Synonym Protein Names: | Atrophin-1-like protein; Atrophin-1-related protein |
Protein Family: | Arginine-glutamic acid dipeptide repeats protein |
UniProt Gene Name: | RERE |
UniProt Entry Name: | RERE_HUMAN |