RCOR1 Antibody, FITC conjugated (PACO46164)
- SKU:
- PACO46164
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | RCOR1 Antibody, FITC conjugated (PACO46164) |
抗体コード: | PACO46164 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human REST corepressor 1 protein (394-482AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. |
シノニム: | REST corepressor 1 (Protein CoREST), RCOR1, KIAA0071 RCOR |
UniProt Protein Function: | RCOR1: Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Belongs to the CoREST family. |
UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 14q32.31 Cellular Component: nucleoplasm; nucleus; transcription factor complex; transcriptional repressor complex Molecular Function:histone deacetylase activity; protein binding; transcription corepressor activity; transcription factor binding Biological Process: blood coagulation; negative regulation of transcription, DNA-dependent |
NCBI Summary: | This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011] |
UniProt Code: | Q9UKL0 |
NCBI GenInfo Identifier: | 74762776 |
NCBI Gene ID: | 23186 |
NCBI Accession: | Q9UKL0.1 |
UniProt Secondary Accession: | Q9UKL0,Q15044, Q6P2I9, Q86VG5, |
UniProt Related Accession: | Q9UKL0 |
Molecular Weight: | 53,028 Da |
NCBI Full Name: | REST corepressor 1 |
NCBI Synonym Full Names: | REST corepressor 1 |
NCBI Official Symbol: | RCOR1 |
NCBI Official Synonym Symbols: | RCOR; COREST |
NCBI Protein Information: | REST corepressor 1 |
UniProt Protein Name: | REST corepressor 1 |
UniProt Synonym Protein Names: | Protein CoREST |
Protein Family: | REST corepressor |
UniProt Gene Name: | RCOR1 |
UniProt Entry Name: | RCOR1_HUMAN |