RBSN Antibody, Biotin conjugated (PACO41901)
- SKU:
- PACO41901
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | RBSN Antibody, Biotin conjugated (PACO41901) |
抗体コード: | PACO41901 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Rabenosyn-5 protein (201-500AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3). Plays a role in the recycling of transferrin receptor to the plasma membrane. |
シノニム: | Rabenosyn-5 (110 kDa protein) (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20), RBSN, ZFYVE20 |
UniProt Protein Function: | ZFYVE20: Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3). |
UniProt Protein Details: | Protein type:C2H2-type zinc finger protein; Adaptor/scaffold Chromosomal Location of Human Ortholog: 3p25.1 Cellular Component: early endosome membrane; endosome; endosome membrane; intracellular membrane-bound organelle; plasma membrane Molecular Function:protein binding; Rab GTPase binding; zinc ion binding Biological Process: blood coagulation; endocytosis; endosomal vesicle fusion; endosome transport; Golgi to endosome transport; Golgi to vacuole transport; late endosome to vacuole transport; protein transport; vacuole inheritance |
NCBI Summary: | This gene encodes a protein that belongs to the FYVE zinc finger family of proteins. The encoded protein interacts with Ras-related proteins that regulate membrane trafficking. A missense mutation in this gene is associated with a defect in the early endocytic pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] |
UniProt Code: | Q9H1K0 |
NCBI GenInfo Identifier: | 108935884 |
NCBI Gene ID: | 64145 |
NCBI Accession: | Q9H1K0.2 |
UniProt Secondary Accession: | Q9H1K0,Q3KP30, Q59EY8, Q8NAQ1, B4DWY8, C9J4P5, |
UniProt Related Accession: | Q9H1K0 |
Molecular Weight: | 23,794 Da |
NCBI Full Name: | Rabenosyn-5 |
NCBI Synonym Full Names: | rabenosyn, RAB effector |
NCBI Official Symbol: | RBSN |
NCBI Official Synonym Symbols: | ZFYVE20; Rabenosyn-5 |
NCBI Protein Information: | rabenosyn-5 |
UniProt Protein Name: | Rabenosyn-5 |
UniProt Synonym Protein Names: | 110 kDa protein; FYVE finger-containing Rab5 effector protein rabenosyn-5; RAB effector RBSN |
UniProt Gene Name: | RBSN |
UniProt Entry Name: | RBNS5_HUMAN |