RBP3 Antibody (PACO60801)
- SKU:
- PACO60801
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | RBP3 Antibody (PACO60801) |
抗体コード: | PACO60801 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Retinol-binding protein 3 protein (1146-1246AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
バックグラウンド: | IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina. |
シノニム: | Retinol-binding protein 3 (Interphotoreceptor retinoid-binding protein) (IRBP) (Interstitial retinol-binding protein), RBP3 |
UniProt Protein Function: | RBP3: IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina. Belongs to the peptidase S41A family. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 10q11.2 Cellular Component: extracellular space; extracellular region; vesicle Molecular Function:retinoid binding; serine-type peptidase activity; retinol binding; retinal binding Biological Process: phototransduction, visible light; visual perception; transport; lipid metabolic process; proteolysis; retinoid metabolic process Disease: Retinitis Pigmentosa 66; Retinitis Pigmentosa |
NCBI Summary: | Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively. [provided by RefSeq, Jul 2008] |
UniProt Code: | P10745 |
NCBI GenInfo Identifier: | 124894 |
NCBI Gene ID: | 5949 |
NCBI Accession: | P10745.2 |
UniProt Secondary Accession: | P10745,Q0QD34, Q5VSR0, Q8IXN0, |
UniProt Related Accession: | P10745 |
Molecular Weight: | 1247 |
NCBI Full Name: | Retinol-binding protein 3 |
NCBI Synonym Full Names: | retinol binding protein 3, interstitial |
NCBI Official Symbol: | RBP3 |
NCBI Official Synonym Symbols: | IRBP; RBPI; RP66; D10S64; D10S65; D10S66 |
NCBI Protein Information: | retinol-binding protein 3; interphotoreceptor retinoid-binding protein |
UniProt Protein Name: | Retinol-binding protein 3 |
UniProt Synonym Protein Names: | Interphotoreceptor retinoid-binding protein; IRBP; Interstitial retinol-binding protein |
Protein Family: | Retinol-binding protein |
UniProt Gene Name: | RBP3 |
UniProt Entry Name: | RET3_HUMAN |