UniProt Protein Function: | RBMY1A1: RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3. |
UniProt Protein Details: | Protein type:RNA splicing Chromosomal Location of Human Ortholog: Yq11.223 Molecular Function:mRNA binding; protein binding Biological Process: regulation of alternative nuclear mRNA splicing, via spliceosome Disease: Spermatogenic Failure, Y-linked, 2 |
NCBI Summary: | This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. This protein is thought to function as a splicing regulator during spermatogenesis. Multiple closely related paralogs of this gene are found in a gene cluster in the AZFb azoospermia factor region of chromosome Y. Most of these related copies are thought to be pseudogenes, though several likely encode functional proteins. [provided by RefSeq, Mar 2016] |
UniProt Code: | P0DJD3 |
NCBI GenInfo Identifier: | 1004170692 |
NCBI Gene ID: | 5940 |
NCBI Accession: | NP_001307873.1 |
UniProt Secondary Accession: | P0DJD3,Q15376, Q15377, Q15414, Q6NSB5, Q86VU6, Q8NHR0 |
UniProt Related Accession: | P0DJD3 |
Molecular Weight: | 55.4kD |
NCBI Full Name: | RNA-binding motif protein, Y chromosome, family 1 member A1 isoform 2 |
NCBI Synonym Full Names: | RNA binding motif protein, Y-linked, family 1, member A1 |
NCBI Official Symbol: | RBMY1A1 |
NCBI Official Synonym Symbols: | RBM; RBM1; RBM2; RBMY; YRRM1; YRRM2; RBMY1C |
NCBI Protein Information: | RNA-binding motif protein, Y chromosome, family 1 member A1 |
UniProt Protein Name: | RNA-binding motif protein, Y chromosome, family 1 member A1 |
UniProt Synonym Protein Names: | RNA-binding motif protein 1; RNA-binding motif protein 2; Y chromosome RNA recognition motif 1; hRBMY |
Protein Family: | RNA-binding motif protein |
UniProt Gene Name: | RBMY1A1 |