RBBP6 Antibody, HRP conjugated (PACO50723)
- SKU:
- PACO50723
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | RBBP6 Antibody, HRP conjugated (PACO50723) |
抗体コード: | PACO50723 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human E3 ubiquitin-protein ligase RBBP6 protein (51-97AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication. |
シノニム: | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis), RBBP6, P2PR PACT RBQ1 |
UniProt Protein Function: | RBBP6: E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell cycle regulation; EC 6.3.2.19; EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Nucleolus; Ubiquitin ligase Chromosomal Location of Human Ortholog: 16p12.2 Cellular Component: nucleoplasm; cytoplasm; nucleolus; microtubule organizing center; chromosome Molecular Function:protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity Biological Process: in utero embryonic development; multicellular organism growth; protein ubiquitination during ubiquitin-dependent protein catabolic process; embryonic organ development |
NCBI Summary: | The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q7Z6E9 |
NCBI GenInfo Identifier: | 74762440 |
NCBI Gene ID: | 5930 |
NCBI Accession: | Q7Z6E9.1 |
UniProt Secondary Accession: | Q7Z6E9,Q147T5, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8 Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4, |
UniProt Related Accession: | Q7Z6E9 |
Molecular Weight: | 1792 |
NCBI Full Name: | E3 ubiquitin-protein ligase RBBP6 |
NCBI Synonym Full Names: | retinoblastoma binding protein 6 |
NCBI Official Symbol: | RBBP6 |
NCBI Official Synonym Symbols: | PACT; MY038; P2P-R; RBQ-1; SNAMA |
NCBI Protein Information: | E3 ubiquitin-protein ligase RBBP6; protein P2P-R; RB-binding Q-protein 1; retinoblastoma-binding Q protein 1; proliferation potential-related protein; p53-associated cellular protein of testis; retinoblastoma-binding protein 6, isoform 3 |
UniProt Protein Name: | E3 ubiquitin-protein ligase RBBP6 |
UniProt Synonym Protein Names: | Proliferation potential-related protein; Protein P2P-R; Retinoblastoma-binding Q protein 1; RBQ-1; Retinoblastoma-binding protein 6; p53-associated cellular protein of testis |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | RBBP6 |
UniProt Entry Name: | RBBP6_HUMAN |