RBBP5 Antibody (PACO43556)
- SKU:
- PACO43556
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | RBBP5 Antibody (PACO43556) |
抗体コード: | PACO43556 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Retinoblastoma-binding protein 5 protein (319-538AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO43556 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human epityphlon tissue using PACO43556 at dilution of 1:100. |
バックグラウンド: | In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid, (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. |
シノニム: | Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3), RBBP5, RBQ3 |
UniProt Protein Function: | RBBP5: As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Core component of several methyltransferase-containing complexes including MLL1/MLL, ASCOM, MLL2/MLL3 and MLL3/MLL4. Each complex is at least composed of ASH2L, RBBP5, DPY30, WDR5, one or more specific histone methyltransferases (MLL, MLL2, MLL3 and MLL4), and the facultative components C16orf53/PA1, C17orf49, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with WDR5 and ASH2L; the interaction is direct. Interacts with WDR82 and SETD1A. Ubiquitously expressed. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 1q32 Cellular Component: histone methyltransferase complex; nucleolus; nucleoplasm; nucleus Molecular Function:histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; methylated histone residue binding; protein binding Biological Process: histone H3-K4 methylation; response to DNA damage stimulus; response to estrogen stimulus |
NCBI Summary: | This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2010] |
UniProt Code: | Q15291 |
NCBI GenInfo Identifier: | 209572664 |
NCBI Gene ID: | 5929 |
NCBI Accession: | Q15291.2 |
UniProt Secondary Accession: | Q15291,Q7Z6D8, Q8NDZ7, A8K272, |
UniProt Related Accession: | Q15291 |
Molecular Weight: | 55,072 Da |
NCBI Full Name: | Retinoblastoma-binding protein 5 |
NCBI Synonym Full Names: | RB binding protein 5, histone lysine methyltransferase complex subunit |
NCBI Official Symbol: | RBBP5 |
NCBI Official Synonym Symbols: | RBQ3; SWD1 |
NCBI Protein Information: | retinoblastoma-binding protein 5 |
UniProt Protein Name: | Retinoblastoma-binding protein 5 |
UniProt Synonym Protein Names: | Retinoblastoma-binding protein RBQ-3 |
Protein Family: | Retinoblastoma-binding protein |
UniProt Gene Name: | RBBP5 |
UniProt Entry Name: | RBBP5_HUMAN |