RARRES2 Antibody, FITC conjugated (PACO32910)
- SKU:
- PACO32910
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | RARRES2 Antibody, FITC conjugated (PACO32910) |
抗体コード: | PACO32910 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Retinoic acid, receptor responder protein 2 protein (21-157AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease. Exhibits an antimicrobial function in the skin. |
シノニム: | Retinoic acid, receptor responder protein 2 (Chemerin) (RAR-responsive protein TIG2) (Tazarotene-induced gene 2 protein), RARRES2, TIG2 |
UniProt Protein Function: | RARRES2: Inhibited in psoriatic lesions. Activated by tazarotene in skin rafts and in the epidermis of psoriatic lesions. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 7q36.1 Cellular Component: extracellular matrix; extracellular region Molecular Function:protein binding; receptor binding Biological Process: cell differentiation; chemotaxis; embryonic gut development; in utero embryonic development; inflammatory response; positive regulation of chemotaxis; positive regulation of fat cell differentiation; positive regulation of protein amino acid phosphorylation; regulation of lipid catabolic process; retinoid metabolic process |
NCBI Summary: | This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine and as an antimicrobial protein with activity against bacteria and fungi. [provided by RefSeq, Nov 2014] |
UniProt Code: | Q99969 |
NCBI GenInfo Identifier: | 6226227 |
NCBI Gene ID: | 5919 |
NCBI Accession: | Q99969.1 |
UniProt Secondary Accession: | Q99969,Q7LE02, |
UniProt Related Accession: | Q99969 |
Molecular Weight: | 18,618 Da |
NCBI Full Name: | Retinoic acid receptor responder protein 2 |
NCBI Synonym Full Names: | retinoic acid receptor responder 2 |
NCBI Official Symbol: | RARRES2 |
NCBI Official Synonym Symbols: | TIG2; HP10433 |
NCBI Protein Information: | retinoic acid receptor responder protein 2 |
UniProt Protein Name: | Retinoic acid receptor responder protein 2 |
UniProt Synonym Protein Names: | Chemerin; RAR-responsive protein TIG2; Tazarotene-induced gene 2 protein |
Protein Family: | Retinoic acid receptor responder protein |
UniProt Gene Name: | RARRES2 |
UniProt Entry Name: | RARR2_HUMAN |