RANBP1 Antibody, Biotin conjugated (PACO46157)
- SKU:
- PACO46157
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | RANBP1 Antibody, Biotin conjugated (PACO46157) |
抗体コード: | PACO46157 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Ran-specific GTPase-activating protein (52-111AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acid, across the nuclear membrane. |
シノニム: | Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1), RANBP1 |
UniProt Protein Function: | RANBP1: a Ran-binding protein that functions in nuclear trafficking, mitosis, chromosomal segregation, and ciliogenesis. Controls both nuclear import and export. Contains a Ran binding domain and a C-terminal nuclear export signal. Following export from the nucleus, forms a complex with RanGTP and XPO1/cargo, leading to dissociation of cargo from XPO1. Stimulates RanGAP1 association with RanGTP, facilitating RanGTP hydrolysis to RanGDP. Stabilizes and regulates the formation of a RanGDP-importin/NLS receptor-RanBP1 complex during nuclear import. Controls RanGTP distribution along mitotic microtubules, which localizes critical factors, such as cyclin B1 and DLG7, to mitotic microtubles and regulates chromosome segregation. Knock down or overexpression experiments affect cellular ciliogenesis by regulating the local RanGTP concentation at the base of cilia.Belongs to the RANBP1 family. |
UniProt Protein Details: | Protein type:G protein regulator, misc.; Microtubule-binding; Cell cycle regulation Chromosomal Location of Human Ortholog: 22q11.21 Cellular Component: cytoplasm; nuclear envelope; nucleus Molecular Function:GDP-dissociation inhibitor activity; Ran GTPase binding; GTPase activator activity Biological Process: intracellular transport; viral reproduction; regulation of catalytic activity; signal transduction; positive regulation of GTPase activity |
NCBI Summary: | This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
UniProt Code: | P43487 |
NCBI GenInfo Identifier: | 520975477 |
NCBI Gene ID: | 5902 |
NCBI Accession: | NP_001265568.1 |
UniProt Related Accession: | P43487 |
Molecular Weight: | |
NCBI Full Name: | ran-specific GTPase-activating protein isoform 1 |
NCBI Synonym Full Names: | RAN binding protein 1 |
NCBI Official Symbol: | RANBP1 |
NCBI Official Synonym Symbols: | HTF9A |
NCBI Protein Information: | ran-specific GTPase-activating protein |
UniProt Protein Name: | Ran-specific GTPase-activating protein |
UniProt Synonym Protein Names: | Ran-binding protein 1; RanBP1 |
UniProt Gene Name: | RANBP1 |
UniProt Entry Name: | RANG_HUMAN |